Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats

2021 · Harm · Low evidence

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HarmLow evidencePaper 1127

Study snapshot

Publicationmanual · 2021

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats Gabriel Martiñón-Gutiérrez, María Luna-Castro, Rolando Hernández-Muñoz. Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats. Sci Rep. 2021 Jun 3;11(1):11666. doi: 10.1038/s41598-021-91228-w. Abstract The exposure to extremely low-frequency electromagnetic fields (EMFs) could adversely affect the endocrine system and cellular proliferative response. Nonetheless, the use of 60-Hz EMFs in the form of magneto-therapy exerts beneficial actions on human health but can also induce hyperglycaemia. Therefore, the present study was aimed to search for metabolic responses of fed or fasted male rats to a single EMF exposure. We performed a 15 min-single exposure to 60-Hz (3.8 mT, intensity) EMF, and determined serum levels of glucose, lipids, and indicators of cellular redox state and energy parameters. A single exposure to a 60-Hz EMF induced hyperglycaemia in both animal groups, and an attenuated second serum insulin peak. The 60-Hz EMF also decreased free fatty acids and lactate serum levels, oppositely increasing pyruvate and acetoacetate levels. Significant increases in blood glucose level and rat's glucose metabolism were related to a more oxidized cellular redox state and variations in insulin and glucagon secretion. The 60-Hz EMF's effects were not modified in animals previously subjected to chronic EMFs exposure (14 days). In conclusion, increased serum glucose levels and glucose metabolism induced by a single 60-Hz EMF exposure were closely related to the cellular redox state and the insulin/glucagon ratio. Open access paper: ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationFed or fasted male rats

Sample sizeNot supplied

ExposureELF · 0.06 MHz · Single 15 min exposure; prior chronic exposure mentioned (14 days)

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

A single 15-minute exposure to a 60-Hz (3.8 mT) EMF induced hyperglycaemia in both fed and fasted male rats and was associated with an attenuated second serum insulin peak. The exposure decreased serum free fatty acids and lactate, and increased pyruvate and acetoacetate; changes in glucose metabolism were related to a more oxidized cellular redox state and variations in insulin and glucagon secretion. Effects were reported as not modified in animals previously subjected to chronic EMF exposure for 14 days.

Outcomes measured

Serum glucose (hyperglycaemia)
Serum insulin (second peak attenuation)
Glucagon secretion/insulin:glucagon ratio
Serum lipids (free fatty acids)
Serum lactate
Serum pyruvate
Serum acetoacetate
Indicators of cellular redox state
Energy parameters

Limitations

Sample size not reported in provided abstract/metadata
Exposure source/setup not specified in provided abstract/metadata
Only male rats studied (generalizability to other sexes/species not addressed in provided abstract)

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.06,
    "sar_wkg": null,
    "duration": "Single 15 min exposure; prior chronic exposure mentioned (14 days)"
  },
  "population": "Fed or fasted male rats",
  "sample_size": null,
  "outcomes": [
    "Serum glucose (hyperglycaemia)",
    "Serum insulin (second peak attenuation)",
    "Glucagon secretion/insulin:glucagon ratio",
    "Serum lipids (free fatty acids)",
    "Serum lactate",
    "Serum pyruvate",
    "Serum acetoacetate",
    "Indicators of cellular redox state",
    "Energy parameters"
  ],
  "main_findings": "A single 15-minute exposure to a 60-Hz (3.8 mT) EMF induced hyperglycaemia in both fed and fasted male rats and was associated with an attenuated second serum insulin peak. The exposure decreased serum free fatty acids and lactate, and increased pyruvate and acetoacetate; changes in glucose metabolism were related to a more oxidized cellular redox state and variations in insulin and glucagon secretion. Effects were reported as not modified in animals previously subjected to chronic EMF exposure for 14 days.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Exposure source/setup not specified in provided abstract/metadata",
    "Only male rats studied (generalizability to other sexes/species not addressed in provided abstract)"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low-frequency",
    "ELF EMF",
    "60-Hz magnetic field",
    "3.8 mT",
    "hyperglycaemia",
    "insulin",
    "glucagon",
    "insulin/glucagon ratio",
    "redox state",
    "glucose metabolism",
    "rats"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.25,
      "reason": "Study involves 60-Hz extremely low-frequency magnetic field exposure, relevant to power-frequency exposure contexts (though source not specified)."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1038/s41598-021-91228-w
PubMed: Not supplied

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