The exposure to extremely low frequency electromagnetic-fields inhibits the growth and potentiates the sensitivity to chemotherapy of bidimensional and tridimensional human osteosarcoma models.
← Research streamA specific ELF-EMF exposure inhibited proliferation in all osteosarcoma models tested and modulated mitochondrial metabolism. Concomitant ELF-EMF exposure increased the effectiveness of several chemotherapeutic drugs (cisplatinum, methotrexate, ifosfamide, do…
Study snapshot
Abstract
We previously established a thermodynamical model to calculate the specific frequencies of extremely low frequency-electromagnetic field (ELF-EMF) able to arrest the growth of cancer cells. In the present study, for the first time, we investigated the efficacy of this technology on osteosarcoma, and we applied a precise frequency of the electromagnetic field on three human osteosarcoma cell lines, grown as adherent cells and spheroids. We evaluated the antitumour efficacy of irradiation in terms of response to chemotherapeutic treatments, which is usually poor in this type of cancer. Importantly, the results of this novel combinatorial approach revealed that the specific exposure can potentiate the efficacy of several chemotherapeutic drugs, both on bidimensional and tridimensional cancer models. The effectiveness of cisplatinum, methotrexate, ifosfamide and doxorubicin was greatly increased by the concomitant application of the specific ELF-EMF. Moreover, our experiments confirmed that ELF-EMF inhibited the proliferation and modulated the mitochondrial metabolism of all cancer models tested, whereas mesenchymal cells were not affected. The latter finding is extremely valuable, given the importance of preserving the cell reservoir necessary for tissue regeneration after chemotherapy. Altogether, this novel evidence opens new avenues to the clinical applications of ELF-EMF in oncology.
AI evidence extraction
Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.
Main findings
A specific ELF-EMF exposure inhibited proliferation in all osteosarcoma models tested and modulated mitochondrial metabolism. Concomitant ELF-EMF exposure increased the effectiveness of several chemotherapeutic drugs (cisplatinum, methotrexate, ifosfamide, doxorubicin) in both 2D and 3D models, while mesenchymal cells were reported as not affected.
Outcomes measured
- Cancer cell growth/proliferation
- Sensitivity/response to chemotherapy (cisplatinum, methotrexate, ifosfamide, doxorubicin)
- Mitochondrial metabolism modulation
- Effects on mesenchymal cells
Limitations
- In vitro study (cell lines and spheroids); clinical relevance not established in the abstract
- Exposure parameters (exact frequency, field strength, duration) not reported in the abstract
- Sample sizes/replicates and statistical details not provided in the abstract
View raw extracted JSON
{
"study_type": "in_vitro",
"exposure": {
"band": "ELF",
"source": null,
"frequency_mhz": null,
"sar_wkg": null,
"duration": null
},
"population": "Three human osteosarcoma cell lines grown as adherent cells (2D) and spheroids (3D); mesenchymal cells also tested",
"sample_size": null,
"outcomes": [
"Cancer cell growth/proliferation",
"Sensitivity/response to chemotherapy (cisplatinum, methotrexate, ifosfamide, doxorubicin)",
"Mitochondrial metabolism modulation",
"Effects on mesenchymal cells"
],
"main_findings": "A specific ELF-EMF exposure inhibited proliferation in all osteosarcoma models tested and modulated mitochondrial metabolism. Concomitant ELF-EMF exposure increased the effectiveness of several chemotherapeutic drugs (cisplatinum, methotrexate, ifosfamide, doxorubicin) in both 2D and 3D models, while mesenchymal cells were reported as not affected.",
"effect_direction": "benefit",
"limitations": [
"In vitro study (cell lines and spheroids); clinical relevance not established in the abstract",
"Exposure parameters (exact frequency, field strength, duration) not reported in the abstract",
"Sample sizes/replicates and statistical details not provided in the abstract"
],
"evidence_strength": "low",
"confidence": 0.74,
"peer_reviewed_likely": "yes",
"keywords": [
"extremely low frequency",
"ELF-EMF",
"electromagnetic field",
"osteosarcoma",
"cell lines",
"spheroids",
"chemotherapy sensitization",
"cisplatinum",
"methotrexate",
"ifosfamide",
"doxorubicin",
"mitochondrial metabolism"
],
"suggested_hubs": []
}AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.
Identifiers and source
DOI: 10.1016/j.biopha.2024.117162
PubMed: 39024997
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