[Effect of an industrial-frequency electromagnetic field on protein biosynthesic processes of embryonal fibroblasts in tissue culture].

Tsitologiia · 1980 · Harm · Low evidence

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HarmLow evidencePaper 5501

Study snapshot

PublicationTsitologiia · 1980

Study typein_vitro

Reported directionHarm

Evidence ratingLow

Abstract

Using radioautography, the influence of the industrial frequency electromagnetic field (50 cps) (EMF i/f), with the tension of 50 and 150 kv/m was studied, on the synthesis of collagen and non-collagen proteins in cultured fibroblast-like human embryo cells in the presence and absense in the medium of adrenaline and of cyclic adenosine monophosphate (cAMP). The EMF depresses protein proportionally to its intesity and duration. The specific function of fibroblasts -- the synthesis of collagen -- is subject to this influence to a great extent. The preliminary administration of adrenaline or cAMP prevented the above changes. The cyclic AMP exerted a much stronger protective effect.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionharm

PopulationCultured fibroblast-like human embryo cells (embryonal fibroblasts)

Sample sizeNot supplied

ExposureELF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In cultured fibroblast-like human embryo cells, exposure to an industrial-frequency electromagnetic field (50 cps) at 50 or 150 kV/m depressed protein synthesis proportionally to field intensity and duration, with collagen synthesis affected to a greater extent. Preliminary administration of adrenaline or cAMP prevented these changes, with cAMP described as having a stronger protective effect.

Outcomes measured

Collagen protein synthesis
Non-collagen protein synthesis
Effect modification by adrenaline
Effect modification by cyclic adenosine monophosphate (cAMP)

Limitations

In vitro tissue culture model; findings may not generalize to in vivo human exposure
Sample size not reported in abstract
Exposure duration not specified in abstract
Details of experimental design and statistical analysis not provided in abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": "other",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Cultured fibroblast-like human embryo cells (embryonal fibroblasts)",
  "sample_size": null,
  "outcomes": [
    "Collagen protein synthesis",
    "Non-collagen protein synthesis",
    "Effect modification by adrenaline",
    "Effect modification by cyclic adenosine monophosphate (cAMP)"
  ],
  "main_findings": "In cultured fibroblast-like human embryo cells, exposure to an industrial-frequency electromagnetic field (50 cps) at 50 or 150 kV/m depressed protein synthesis proportionally to field intensity and duration, with collagen synthesis affected to a greater extent. Preliminary administration of adrenaline or cAMP prevented these changes, with cAMP described as having a stronger protective effect.",
  "effect_direction": "harm",
  "limitations": [
    "In vitro tissue culture model; findings may not generalize to in vivo human exposure",
    "Sample size not reported in abstract",
    "Exposure duration not specified in abstract",
    "Details of experimental design and statistical analysis not provided in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "industrial frequency",
    "50 cps",
    "ELF",
    "electric field",
    "kV/m",
    "fibroblasts",
    "human embryo cells",
    "collagen synthesis",
    "protein synthesis",
    "adrenaline",
    "cAMP",
    "radioautography"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.35,
      "reason": "Study uses industrial-frequency (50 cps) field exposure, relevant to occupational/industrial EMF contexts."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 6251585

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