Reduced mitogenic stimulation of human lymphocytes by extremely low frequency electromagnetic fields.

FEBS letters · 1983 · Harm · Very low evidence

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HarmVery low evidencePaper 5500

Study snapshot

PublicationFEBS letters · 1983

Study typein_vitro

Reported directionHarm

Evidence ratingVery low

Abstract

Blastogenesis of human peripheral blood lymphocytes stimulated in vitro by non-specific mitogens (PHA, ConA, PWM) upon exposure to extremely low frequency EMF has been studied. Different frequencies of square waveforms have been used. PHA-stimulation resulted in strong inhibitions as measured by [3H]thymidine incorporation. A frequency window (3-50 Hz) within which ConA-induced blastogenesis was significantly inhibited has been individuated. The mitogenic effect of PWM was significantly affected only at 3 Hz.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionharm

PopulationHuman peripheral blood lymphocytes (in vitro)

Sample sizeNot supplied

ExposureELF

Evidence strengthVery lowConfidence: 74% · Peer reviewed: yes

Main findings

In vitro exposure to extremely low frequency EMF (square waveforms) was associated with reduced mitogen-stimulated blastogenesis of human peripheral blood lymphocytes. PHA stimulation showed strong inhibition by [3H]thymidine incorporation; ConA-induced blastogenesis was significantly inhibited within a 3–50 Hz frequency window; PWM effects were significantly affected only at 3 Hz.

Outcomes measured

Lymphocyte blastogenesis/mitogenic stimulation (PHA, ConA, PWM)
[3H]thymidine incorporation

Limitations

No sample size reported in abstract
Exposure intensity/field strength not reported in abstract
Exposure duration not reported in abstract
In vitro study; generalizability to in vivo health outcomes is unclear

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Human peripheral blood lymphocytes (in vitro)",
  "sample_size": null,
  "outcomes": [
    "Lymphocyte blastogenesis/mitogenic stimulation (PHA, ConA, PWM)",
    "[3H]thymidine incorporation"
  ],
  "main_findings": "In vitro exposure to extremely low frequency EMF (square waveforms) was associated with reduced mitogen-stimulated blastogenesis of human peripheral blood lymphocytes. PHA stimulation showed strong inhibition by [3H]thymidine incorporation; ConA-induced blastogenesis was significantly inhibited within a 3–50 Hz frequency window; PWM effects were significantly affected only at 3 Hz.",
  "effect_direction": "harm",
  "limitations": [
    "No sample size reported in abstract",
    "Exposure intensity/field strength not reported in abstract",
    "Exposure duration not reported in abstract",
    "In vitro study; generalizability to in vivo health outcomes is unclear"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency",
    "ELF",
    "electromagnetic fields",
    "square waveform",
    "frequency window",
    "lymphocytes",
    "blastogenesis",
    "mitogens",
    "PHA",
    "ConA",
    "PWM",
    "thymidine incorporation"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/0014-5793(83)81069-2
PubMed: 6617888

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