RF Safe

Augmentation of mucosal adaptation following small-bowel resection by electromagnetic field stimulation in rats.

The Tokai journal of experimental and clinical medicine · 1993 · Benefit · Low evidence

← Research stream
BenefitLow evidencePaper 5465

In two groups of 10 rats undergoing 70% jejunoileal resection, the group receiving EMF stimulation (43.20 gauss for 10 days) showed augmented mucosal adaptation in the proximal and distal remaining small intestine compared with no stimulation.

Study snapshot

PublicationThe Tokai journal of experimental and clinical medicine · 1993
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

Survival following massive resection of the small intestine is often possible due to substantial hyperplasia of the mucosal surface in the remaining small intestine. While nutrients provide the major stimulus for hyperplasia in the clinical setting, the availability of drugs to augment this process would have obvious therapeutic implications. Electromagnetic field stimulation (EMF) of connective tissue and skin increased the DNA and messenger RNA and protein synthesis in experimental studies. We evaluated the ability of electromagnetic field stimulation to augment mucosal hyperplasia following massive small bowel resection in the rat. Two groups of 10 Wistar rats, 250 gr body weight, were subjected to 70% jejunoileal resection. The first group received EMF stimulation for ten days at a dosage of 43.20 gauss, the second group did not receive any stimulation. After fourteen days, segmental evaluation of mucosal mass in the remaining small intestine was determined by measuring mucosal protein, and disaccharidase levels, as well as intestinal length and circumference. EMF stimulation appears to augment mucosal adaptation following massive small bowel resection in rat, in the proximal and distal small intestine.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationWistar rats after 70% jejunoileal resection
Sample size20
Exposure10 days
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In two groups of 10 rats undergoing 70% jejunoileal resection, the group receiving EMF stimulation (43.20 gauss for 10 days) showed augmented mucosal adaptation in the proximal and distal remaining small intestine compared with no stimulation.

Outcomes measured

  • Mucosal adaptation/hyperplasia (mucosal mass)
  • Mucosal protein
  • Disaccharidase levels
  • Intestinal length
  • Intestinal circumference

Limitations

  • Frequency and other exposure parameters beyond magnetic field strength (gauss) not reported in abstract
  • Short follow-up duration (14 days)
  • Animal model; generalizability to humans not addressed in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "electromagnetic field stimulation",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "10 days"
  },
  "population": "Wistar rats after 70% jejunoileal resection",
  "sample_size": 20,
  "outcomes": [
    "Mucosal adaptation/hyperplasia (mucosal mass)",
    "Mucosal protein",
    "Disaccharidase levels",
    "Intestinal length",
    "Intestinal circumference"
  ],
  "main_findings": "In two groups of 10 rats undergoing 70% jejunoileal resection, the group receiving EMF stimulation (43.20 gauss for 10 days) showed augmented mucosal adaptation in the proximal and distal remaining small intestine compared with no stimulation.",
  "effect_direction": "benefit",
  "limitations": [
    "Frequency and other exposure parameters beyond magnetic field strength (gauss) not reported in abstract",
    "Short follow-up duration (14 days)",
    "Animal model; generalizability to humans not addressed in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electromagnetic field stimulation",
    "small bowel resection",
    "jejunoileal resection",
    "mucosal adaptation",
    "mucosal hyperplasia",
    "rats",
    "Wistar",
    "disaccharidase",
    "mucosal protein"
  ],
  "suggested_hubs": []
}
AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 7940605

Read the original paper →

Related papers

← Back to the Research Library