[Mechanism of action of electromagnetic fields biologically adequate to man].

Vestnik Rossiiskoi akademii meditsinskikh nauk · 1996 · Benefit · Insufficient evidence

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BenefitInsufficient evidencePaper 5419

Study snapshot

PublicationVestnik Rossiiskoi akademii meditsinskikh nauk · 1996

Study typeother

Reported directionBenefit

Evidence ratingInsufficient

Abstract

The paper analyzes 10-year experience in making experimental observations and clinically using electromagnetic fields (EMF) biologically adequate to man. Basic investigations of the electromechanical process that lead to the occurrence of currents in the bone tissue and blood vascular walls in their functional deformation were conducted. They showed that the piezoelectric effect is the most marked in the intact bone tissue. Experimental studies determined the amplitude and shape of impulses of currents emerging in the intact bone tissue of the extremities and in the walls of blood vessels during pulse blood filling. The bioelectric tissue metabolism changes in various human locomotor abnormalities. The lost part in the diseased area can be restored by means of external EMF. On this basis, devices for human biologically adequate electromagnetic therapy were designed. The efficiency of each session of electromagnetic therapy was evaluated from the normalization of blood circulation in the diseased area. The efficiency of this therapy in vascular disease was noted to depend on the synchronization of the generated electromagnetic pulse with the pulse wave of a patient and its phases. An experiment on 13 intact mongrel dogs was made to reveal the impact of EMF biologically adequate to man on bone marrow hemopoiesis. EMF 2 was found to have a stimulating effect on granulocytopoiesis. Platelet counts were elevated in the peripheral blood of animals. Analysing 2000 clinical cases and canine experimental findings provided evidence for the following mechanism of action of the electromagnetic fields biologically adequate to man. The fields exert a primary initial and virtually rapid action on the active areas of nerve structures and smooth muscle of blood vascular walls. They show a primary, but slower action on blood cells and on the vascular endothelial structure. There may be a secondary impact of EMF on some endocrine glands, which causes changes in the protein metabolism of a biological object and appears as stimulation of granulocytopoiesis and depot platelet release into the peripheral blood stream.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionbenefit

PopulationHumans (clinical cases) and intact mongrel dogs (animal experiment)

Sample size2013

Exposureeach session evaluated; 10-year experience mentioned

Evidence strengthInsufficientConfidence: 62% · Peer reviewed: yes

Main findings

Experimental work characterized impulses of currents in intact bone tissue and blood vessel walls and reported that the piezoelectric effect was most marked in intact bone tissue. In clinical use, therapy session efficiency was evaluated by normalization of blood circulation in the diseased area and was noted to depend on synchronization of the generated electromagnetic pulse with the patient’s pulse wave. In 13 intact mongrel dogs, an EMF condition described as “EMF 2” was reported to stimulate granulocytopoiesis and elevate platelet counts; the authors propose a mechanism involving rapid effects on nerve structures and vascular smooth muscle, slower effects on blood cells/endothelium, and possible secondary endocrine impacts.

Outcomes measured

Currents induced in bone tissue and blood vessel walls during functional deformation/pulse blood filling
Normalization of blood circulation in diseased area during electromagnetic therapy
Bone marrow hemopoiesis (granulocytopoiesis)
Peripheral blood platelet counts
Proposed mechanism of action involving nerve structures, smooth muscle, blood cells, endothelium, and possible endocrine effects/protein metabolism changes

Limitations

EMF exposure parameters (frequency, intensity, waveform details beyond synchronization, and dosimetry) are not provided in the abstract.
Clinical outcomes are described generally (e.g., normalization of blood circulation) without quantitative results or comparison groups in the abstract.
Human clinical cases are summarized (2000 cases) without details on study design, inclusion criteria, controls, or statistical analysis in the abstract.
Animal experiment details beyond sample size (n=13) and outcome direction are limited in the abstract.

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "therapeutic EMF (biologically adequate to man)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "each session evaluated; 10-year experience mentioned"
  },
  "population": "Humans (clinical cases) and intact mongrel dogs (animal experiment)",
  "sample_size": 2013,
  "outcomes": [
    "Currents induced in bone tissue and blood vessel walls during functional deformation/pulse blood filling",
    "Normalization of blood circulation in diseased area during electromagnetic therapy",
    "Bone marrow hemopoiesis (granulocytopoiesis)",
    "Peripheral blood platelet counts",
    "Proposed mechanism of action involving nerve structures, smooth muscle, blood cells, endothelium, and possible endocrine effects/protein metabolism changes"
  ],
  "main_findings": "Experimental work characterized impulses of currents in intact bone tissue and blood vessel walls and reported that the piezoelectric effect was most marked in intact bone tissue. In clinical use, therapy session efficiency was evaluated by normalization of blood circulation in the diseased area and was noted to depend on synchronization of the generated electromagnetic pulse with the patient’s pulse wave. In 13 intact mongrel dogs, an EMF condition described as “EMF 2” was reported to stimulate granulocytopoiesis and elevate platelet counts; the authors propose a mechanism involving rapid effects on nerve structures and vascular smooth muscle, slower effects on blood cells/endothelium, and possible secondary endocrine impacts.",
  "effect_direction": "benefit",
  "limitations": [
    "EMF exposure parameters (frequency, intensity, waveform details beyond synchronization, and dosimetry) are not provided in the abstract.",
    "Clinical outcomes are described generally (e.g., normalization of blood circulation) without quantitative results or comparison groups in the abstract.",
    "Human clinical cases are summarized (2000 cases) without details on study design, inclusion criteria, controls, or statistical analysis in the abstract.",
    "Animal experiment details beyond sample size (n=13) and outcome direction are limited in the abstract."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.62,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electromagnetic therapy",
    "biologically adequate EMF",
    "piezoelectric effect",
    "bone tissue currents",
    "vascular walls",
    "blood circulation",
    "granulocytopoiesis",
    "platelets",
    "hemopoiesis",
    "mechanism of action"
  ],
  "suggested_hubs": [
    {
      "slug": "emf-therapy",
      "weight": 0.9,
      "reason": "Focuses on therapeutic use of externally applied electromagnetic fields and proposed mechanisms."
    },
    {
      "slug": "animal-studies",
      "weight": 0.45,
      "reason": "Includes an experiment in 13 intact mongrel dogs assessing hematopoietic outcomes."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 8924828

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