Static magnetic field on behavior, hematological parameters and organ damage in spontaneously hypertensive rats

Ecotoxicology and environmental safety · 2020 · Mixed · Low evidence

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MixedLow evidencePaper 2270

Study snapshot

PublicationEcotoxicology and environmental safety · 2020

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Static magnetic field on behavior, hematological parameters and organ damage in spontaneously hypertensive rats Tatjana Tasić, Maja Lozić, Sofija Glumac, Marija Stanković, Ivan Milovanovich, Drago M Djordjevich, Alexander M Trbovich, Nina Japundžić-Žigon, Silvio R De Luka. Static magnetic field on behavior, hematological parameters and organ damage in spontaneously hypertensive rats. Ecotoxicol Environ Saf. 2020 Sep 5;207:111085. doi: 10.1016/j.ecoenv.2020.111085. Abstract Previous studies showed contradictory results of static magnetic field (SMF) influence on behavior, hematological parameters and organ damage. The aim of this study was to investigate influence of subchronic continuous exposure to upward and downward oriented SMF of moderate intensity on behavior, hematological characteristics, heart and kidney tissue of spontaneously hypertensive rats. SH rats exposed to downward oriented SMF demonstrated lack of anxious-like behavior. SMF of either orientation caused decrease in the number of platelets in peripheral blood, granulocytes in the spleen and bone marrow and increase in the number of erythrocytes in the spleen, in both exposed groups. We also demonstrated that spontaneously hypertensive rats exposed to upward oriented SMF exhibited decreased lymphocytes count in blood, decreased bone marrow erythrocytes count and rats exposed to downward oriented SMF had increased lymphocytes count in bone marrow. The results showed adverse effect of differently oriented SMF on hematological parameters of spontaneously hypertensive rats. Also, exposure to different oriented SMF didn't affect their heart and kidney morphological characteristics. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationSpontaneously hypertensive rats

Sample sizeNot supplied

Exposurestatic · subchronic continuous exposure

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Rats exposed to downward oriented SMF showed lack of anxious-like behavior. SMF of either orientation decreased platelets in peripheral blood and granulocytes in spleen and bone marrow, and increased erythrocytes in spleen. Upward oriented SMF decreased blood lymphocytes and bone marrow erythrocytes, while downward oriented SMF increased bone marrow lymphocytes; heart and kidney morphological characteristics were not affected.

Outcomes measured

Behavior (anxious-like behavior)
Hematological parameters (platelets, granulocytes, erythrocytes, lymphocytes; spleen and bone marrow cell counts)
Heart morphology
Kidney morphology

Limitations

Magnetic field intensity described only as 'moderate' (no quantitative exposure level provided in abstract)
Sample size not reported in abstract
Subchronic exposure duration not quantified in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "static",
    "source": "static magnetic field (SMF)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "subchronic continuous exposure"
  },
  "population": "Spontaneously hypertensive rats",
  "sample_size": null,
  "outcomes": [
    "Behavior (anxious-like behavior)",
    "Hematological parameters (platelets, granulocytes, erythrocytes, lymphocytes; spleen and bone marrow cell counts)",
    "Heart morphology",
    "Kidney morphology"
  ],
  "main_findings": "Rats exposed to downward oriented SMF showed lack of anxious-like behavior. SMF of either orientation decreased platelets in peripheral blood and granulocytes in spleen and bone marrow, and increased erythrocytes in spleen. Upward oriented SMF decreased blood lymphocytes and bone marrow erythrocytes, while downward oriented SMF increased bone marrow lymphocytes; heart and kidney morphological characteristics were not affected.",
  "effect_direction": "mixed",
  "limitations": [
    "Magnetic field intensity described only as 'moderate' (no quantitative exposure level provided in abstract)",
    "Sample size not reported in abstract",
    "Subchronic exposure duration not quantified in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "SMF orientation",
    "subchronic exposure",
    "spontaneously hypertensive rats",
    "behavior",
    "anxiety-like behavior",
    "hematology",
    "platelets",
    "granulocytes",
    "erythrocytes",
    "lymphocytes",
    "spleen",
    "bone marrow",
    "heart morphology",
    "kidney morphology"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.ecoenv.2020.111085
PubMed: 32898814

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