Possible associations between ELF electromagnetic fields, DNA damage response processes and childhood leukaemia.

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "12 h post-gamma-ray exposure"
  },
  "population": "human lymphocytes",
  "sample_size": null,
  "outcomes": [
    "Gamma-ray-induced dicentric chromosome exchange",
    "DNA damage response (chromosomal exchange following genotoxic insult)"
  ],
  "main_findings": "In human lymphocytes, exposure to ELF EMF fields of 0.23, 0.47, and 0.7 mT assessed 12 h after gamma-ray exposure showed no support for the hypothesis that ELF EMF compromises DNA damage response by enhancing chromosomal exchange. The study reports sufficient power to exclude an ELF enhancement of chromosomal exchange of 10–15% (2SE).",
  "effect_direction": "no_effect",
  "limitations": [],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF electromagnetic fields",
    "childhood leukaemia",
    "DNA damage response",
    "genotoxic agents",
    "ionising radiation",
    "gamma rays",
    "dicentric chromosome exchange",
    "human lymphocytes",
    "coleukaemogen",
    "chromosomal exchange"
  ],
  "suggested_hubs": [
    {
      "slug": "childhood-leukemia",
      "weight": 0.9,
      "reason": "Discusses epidemiologic association with childhood leukaemia and tests a proposed biological mechanism."
    }
  ]
}