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Acute effects of 60-Hz electromagnetic fields on ex vivo murine lymphocyte and macrophage functions, and in vitro tumor cell growth.

Revista latinoamericana de microbiologia · 2001 · No effect · Low evidence

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No effectLow evidencePaper 3859

Exposure to 60 Hz EMF at 1.0 mT did not alter murine lymphocyte proliferation, macrophage nitric oxide production, or macrophage phagocytosis of Candida albicans. EMF exposure (8 h/day for 6 days) did not affect in vitro growth of the murine lymphoma cell lin…

Study snapshot

PublicationRevista latinoamericana de microbiologia · 2001
Study typeanimal
Reported directionNo effect
Evidence ratingLow

Abstract

Electromagnetic fields (EMFs) have been associated with impairing health. There are data that associate EMFs exposure to incidence of cancer, but there are conflicting results between epidemiological and laboratory studies. Similarly studies on the effect of EMF on the immune system have produced variable results. In the present study, we evaluated the acute effects of 60 Hz EMFs exposure at 1.0 mT, on proliferation of murine thymic lymphocytes, production of nitric oxide and phagocytosis of Candida albicans by peritoneal murine macrophages, as well as the effect of 8 h/day of EMF exposure during 6 days on proliferation of murine lymphoma L5178Y-R cell growth. We observed that exposure to EMF did not alter lymphocyte and macrophage functions, and did not affect in vitro cell growth of the murine lymphoma cell line L5178Y-R.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionno_effect
PopulationMurine thymic lymphocytes and peritoneal murine macrophages (ex vivo); murine lymphoma cell line L5178Y-R (in vitro)
Sample sizeNot supplied
ExposureELF · 0.06 MHz · acute exposure; and 8 h/day for 6 days (tumor cell growth experiment)
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Exposure to 60 Hz EMF at 1.0 mT did not alter murine lymphocyte proliferation, macrophage nitric oxide production, or macrophage phagocytosis of Candida albicans. EMF exposure (8 h/day for 6 days) did not affect in vitro growth of the murine lymphoma cell line L5178Y-R.

Outcomes measured

  • Proliferation of murine thymic lymphocytes
  • Nitric oxide production by peritoneal murine macrophages
  • Phagocytosis of Candida albicans by peritoneal murine macrophages
  • Proliferation/growth of murine lymphoma cell line L5178Y-R

Limitations

  • Sample size not reported in abstract
  • Exposure source/setup not described in abstract
  • Only acute/short-term exposure assessed
  • Endpoints limited to selected immune functions and one tumor cell line
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.06,
    "sar_wkg": null,
    "duration": "acute exposure; and 8 h/day for 6 days (tumor cell growth experiment)"
  },
  "population": "Murine thymic lymphocytes and peritoneal murine macrophages (ex vivo); murine lymphoma cell line L5178Y-R (in vitro)",
  "sample_size": null,
  "outcomes": [
    "Proliferation of murine thymic lymphocytes",
    "Nitric oxide production by peritoneal murine macrophages",
    "Phagocytosis of Candida albicans by peritoneal murine macrophages",
    "Proliferation/growth of murine lymphoma cell line L5178Y-R"
  ],
  "main_findings": "Exposure to 60 Hz EMF at 1.0 mT did not alter murine lymphocyte proliferation, macrophage nitric oxide production, or macrophage phagocytosis of Candida albicans. EMF exposure (8 h/day for 6 days) did not affect in vitro growth of the murine lymphoma cell line L5178Y-R.",
  "effect_direction": "no_effect",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure source/setup not described in abstract",
    "Only acute/short-term exposure assessed",
    "Endpoints limited to selected immune functions and one tumor cell line"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "60 Hz",
    "ELF electromagnetic fields",
    "1.0 mT",
    "murine thymic lymphocytes",
    "peritoneal macrophages",
    "nitric oxide",
    "phagocytosis",
    "Candida albicans",
    "L5178Y-R lymphoma cell line",
    "in vitro",
    "ex vivo"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.25,
      "reason": "Study examines 60 Hz ELF magnetic field exposure (relevant to power-frequency environments), though no specific occupational setting is described."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 17061499

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