Oxidative DNA damage in rats exposed to extremely low frequency electro magnetic fields.

Free radical research · 2005 · Harm · Low evidence

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HarmLow evidencePaper 5193

Rats exposed to ELF-EMF (50 Hz, 0.97 mT) had significantly higher 8OHdG levels in DNA than sham controls at both 50 and 100 days (p<0.001 for both). Plasma TBARS levels were also higher in the exposed group at both time points (p<0.001), and the extent of DNA…

Study snapshot

PublicationFree radical research · 2005

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Extremely low frequency (ELF) electromagnetic field (EMF) is thought to prolong the life of free radicals and can act as a promoter or co-promoter of cancer. 8-hydroxy-2'-deoxyguanosine (8OHdG) is one of the predominant forms of radical-induced lesions to DNA and is a potential tool to asses the cancer risk. We examined the effects of extremely low frequency electro magnetic field (ELF-EMF) (50 Hz, 0.97 mT) on 8OHdG levels in DNA and thiobarbituric acid reactive substances (TBARS) in plasma. To examine the possible time-dependent changes resulting from magnetic field, 8OHdG and TBARS were quantitated at 50 and 100 days. Our results showed that the exposure to ELF-EMF induced oxidative DNA damage and lipid peroxidation (LPO). The 8OHdG levels of exposed group (4.39+/-0.88 and 5.29+/-1.16 8OHdG/dG.10(5), respectively) were significantly higher than sham group at 50 and 100 days (3.02+/-0.63 and 3.46+/-0.38 8OHdG/dG.10(5)) (p<0.001, p<0.001). The higher TBARS levels were also detected in the exposure group both on 50 and 100 days (p<0.001, p<0.001). In addition, the extent of DNA damage and LPO would depend on the exposure time (p<0.05 and p<0.05). Our data may have important implications for the long-term exposure to ELF-EMF which may cause oxidative DNA damage.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationRats

Sample sizeNot supplied

ExposureELF · 50 and 100 days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

8-hydroxy-2'-deoxyguanosine (8OHdG) levels in DNA
Thiobarbituric acid reactive substances (TBARS) in plasma
Oxidative DNA damage
Lipid peroxidation (LPO)

Limitations

Sample size not reported in the provided abstract/metadata
Exposure source/setup details not described in the provided abstract
Only oxidative stress biomarkers reported; no clinical or tumor outcomes reported

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "50 and 100 days"
  },
  "population": "Rats",
  "sample_size": null,
  "outcomes": [
    "8-hydroxy-2'-deoxyguanosine (8OHdG) levels in DNA",
    "Thiobarbituric acid reactive substances (TBARS) in plasma",
    "Oxidative DNA damage",
    "Lipid peroxidation (LPO)"
  ],
  "main_findings": "Rats exposed to ELF-EMF (50 Hz, 0.97 mT) had significantly higher 8OHdG levels in DNA than sham controls at both 50 and 100 days (p<0.001 for both). Plasma TBARS levels were also higher in the exposed group at both time points (p<0.001), and the extent of DNA damage and lipid peroxidation was reported to depend on exposure time (p<0.05).",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in the provided abstract/metadata",
    "Exposure source/setup details not described in the provided abstract",
    "Only oxidative stress biomarkers reported; no clinical or tumor outcomes reported"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF-EMF",
    "50 Hz",
    "0.97 mT",
    "rats",
    "8OHdG",
    "TBARS",
    "oxidative DNA damage",
    "lipid peroxidation"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.25,
      "reason": "Study involves long-term ELF magnetic field exposure (50 Hz), relevant to contexts where such fields occur, though no specific occupational setting is described."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/10715760500043603
PubMed: 15788236

Read the original paper →

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