Alterations of hematological variations in rats exposed to extremely low frequency magnetic fields (50 Hz).

Archives of medical research · 2009 · Mixed · Low evidence

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MixedLow evidencePaper 4941

In rats exposed to 0.97 mT, 50 Hz ELF-EMF for 50 days (3 h/day), eosinophil, hemoglobin, and MPV levels significantly decreased. MPV was significantly lower after 100 days compared with 50 days. No significant differences were reported for multiple other bloo…

Study snapshot

PublicationArchives of medical research · 2009

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

BACKGROUND AND AIMS: The aim of this study was to evaluate the possible effects of in vivo exposure to extremely low frequency electromagnetic fields (ELF-EMF) on whole blood parameters (hematological parameters) in rats. METHODS: Forty eight female Wistar rats, obtained from the Medical Science Application and Research Center, Dicle University, Turkey in 2004 were divided into four separate groups: two exposed groups (0.97 mT, 50 and 100 days, 3h/day) and two controls (sham). RESULTS: Eosinophil, hemoglobin and MPV levels significantly decreased in rats that were exposed to EMF for 50 days. When the data for rats exposed for 50 days and 100 days were compared, it was found that MPV levels in rats exposed for 100 days were significantly lower. There was no significant difference in total leukocyte, neutrofil, lymphocyte, monocyte, eosinophil and basophil counts, or in erythrocyte, Hct, MCH, MCHC, RDW, PLT and PDW levels between the exposed and sham-exposed groups. ELF-EMF exposure had no effect on body weight. Also, liver weight did not show any significant difference between groups. CONCLUSIONS: Our results indicate that the applied ELF-EMF exposure may induce slight but statistically significant alterations in some hematological parameters of rats, within the physiological range.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationFemale Wistar rats

Sample size48

ExposureELF · 50 or 100 days, 3 h/day

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Hematological parameters (whole blood parameters)
Eosinophil level/count
Hemoglobin
Mean platelet volume (MPV)
Total leukocyte count
Neutrophil count
Lymphocyte count
Monocyte count
Basophil count
Erythrocyte count
Hematocrit (Hct)
MCH
MCHC
RDW
Platelet count (PLT)
PDW
Body weight
Liver weight

Limitations

Exposure source/setup not described in the abstract
Only female rats were studied
Many outcomes showed no significant differences; changes reported were described as slight and within physiological range

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "50 or 100 days, 3 h/day"
  },
  "population": "Female Wistar rats",
  "sample_size": 48,
  "outcomes": [
    "Hematological parameters (whole blood parameters)",
    "Eosinophil level/count",
    "Hemoglobin",
    "Mean platelet volume (MPV)",
    "Total leukocyte count",
    "Neutrophil count",
    "Lymphocyte count",
    "Monocyte count",
    "Basophil count",
    "Erythrocyte count",
    "Hematocrit (Hct)",
    "MCH",
    "MCHC",
    "RDW",
    "Platelet count (PLT)",
    "PDW",
    "Body weight",
    "Liver weight"
  ],
  "main_findings": "In rats exposed to 0.97 mT, 50 Hz ELF-EMF for 50 days (3 h/day), eosinophil, hemoglobin, and MPV levels significantly decreased. MPV was significantly lower after 100 days compared with 50 days. No significant differences were reported for multiple other blood counts/indices, body weight, or liver weight between exposed and sham-exposed groups.",
  "effect_direction": "mixed",
  "limitations": [
    "Exposure source/setup not described in the abstract",
    "Only female rats were studied",
    "Many outcomes showed no significant differences; changes reported were described as slight and within physiological range"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency",
    "ELF-EMF",
    "magnetic field",
    "50 Hz",
    "0.97 mT",
    "rats",
    "Wistar",
    "hematology",
    "hemoglobin",
    "eosinophil",
    "mean platelet volume",
    "MPV"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.arcmed.2009.07.001
PubMed: 19766897

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