[Effect of 900Mhz electromagnetic fields on energy metabolism in postnatal rat cerebral cortical neurons].

Wei sheng yan jiu = Journal of hygiene research · 2005 · Harm · Low evidence

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HarmLow evidencePaper 5178

Compared with sham exposure, GluR2 protein in exposed neurons was significantly down-regulated (P<0.01) and intracellular calcium ions were significantly up-regulated (P<0.01). The authors report trends consistent with a dose-response relationship across SAR …

Study snapshot

PublicationWei sheng yan jiu = Journal of hygiene research · 2005

Study typein_vitro

Reported directionHarm

Evidence ratingLow

Abstract

OBJECTIVE: To study the effect of 900MHz low intensity microwave electromagnetic fields (EMF) on AMPA GluR2 and the concentration of intracellular calcium in postnatal rat cerebral cortical neurons. METHODS: Neurons were exposed to low intensity 900MHz continuous microwaves EMF (SAR = 3.22W/kg, 2.23W/kg, 1.15W/kg) for 2 hours per day in 4 or 6 consecutive days and for 12 hours at a time (SAR = 3.22W/kg). Such exposures were carried out to have knowledge of the effect of microwave on protein of GluR2 and intracellular calcium ions. RESULTS: The results of immunochemistry and laser confocal scan showed that compared with sham, protein of GluR2 of exposed neurons were significantly down-regulated (P < 0.01), while intracellular calcium ions were significantly up-regulated (P < 0.01). CONCLUSION: The microwaves play a role of accumulation in the effect on exposed neurons, the trends in dose response relationship were found between the exposure intensity and the effects, effect of the microwave on exposed neurons should be classified as athermal effects of EMF.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionharm

PopulationPostnatal rat cerebral cortical neurons

Sample sizeNot supplied

ExposureRF · 900 MHz · 3.22 W/kg · 2 hours/day for 4 or 6 consecutive days; and 12 hours at a time (SAR=3.22 W/kg)

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

AMPA receptor subunit GluR2 protein expression
Intracellular calcium ion concentration

Limitations

In vitro neuron model; findings may not generalize to whole organisms or humans
Sample size not reported in abstract
Exposure conditions and dosimetry details beyond SAR not provided in abstract
Only two biological endpoints reported (GluR2 protein and intracellular calcium)

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 900,
    "sar_wkg": 3.22,
    "duration": "2 hours/day for 4 or 6 consecutive days; and 12 hours at a time (SAR=3.22 W/kg)"
  },
  "population": "Postnatal rat cerebral cortical neurons",
  "sample_size": null,
  "outcomes": [
    "AMPA receptor subunit GluR2 protein expression",
    "Intracellular calcium ion concentration"
  ],
  "main_findings": "Compared with sham exposure, GluR2 protein in exposed neurons was significantly down-regulated (P<0.01) and intracellular calcium ions were significantly up-regulated (P<0.01). The authors report trends consistent with a dose-response relationship across SAR levels and suggest an accumulation effect with repeated exposure.",
  "effect_direction": "harm",
  "limitations": [
    "In vitro neuron model; findings may not generalize to whole organisms or humans",
    "Sample size not reported in abstract",
    "Exposure conditions and dosimetry details beyond SAR not provided in abstract",
    "Only two biological endpoints reported (GluR2 protein and intracellular calcium)"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "900 MHz",
    "microwave",
    "RF EMF",
    "SAR",
    "GluR2",
    "AMPA receptor",
    "intracellular calcium",
    "postnatal rat",
    "cerebral cortical neurons",
    "athermal effects"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 15952649

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