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ELF magnetic therapy and oxidative balance.

Electromagnetic biology and medicine · 2008 · Benefit · Low evidence

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BenefitLow evidencePaper 4990

In 32 healthy volunteers treated with an ELF magnetic therapy device (Seqex), mean peripheral blood MDA decreased by 53.8% at the end of treatment (p=0.0002). One month later MDA increased relative to end-of-treatment but remained 15.6% lower than baseline (p…

Study snapshot

PublicationElectromagnetic biology and medicine · 2008
Study typeother
Reported directionBenefit
Evidence ratingLow

Abstract

Knowledge about the relationship between exposure to extremely low-frequency (ELF) EMF and formation (or neutralization) of free radicals in the living cells is limited. Studies performed on animals and plants have shown conflicting effects on the relation between EMF and oxidative stress. Very few experiments have been performed on humans. The present study reports on the effects of an ELF magnetic therapy device (Seqex) on oxidative scale in humans. This device supplies complex magnetic signals with specific choices of frequency, intensity, and shape that are based on Liboff's ion cyclotron resonance hypothesis. Thirty-two healthy volunteers were treated using the Seqex cycle. A quantitative determination of oxidative stress was obtained at three time points by measuring Malondialdehyde (MDA) concentrations in peripheral blood before and after the cycle and one month following completion of the cycle. A highly significant reduction in mean MDA (53.8%, p = 0.0002) was found at the end of the treatment. One month later the mean MDA had again risen, but there was still a significant overall reduction of 15.6% (p = 0.010) compared to original values.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother
Effect directionbenefit
Population32 healthy volunteers (humans)
Sample size32
ExposureELF · treated using the Seqex cycle; outcomes measured before and after the cycle and one month later
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In 32 healthy volunteers treated with an ELF magnetic therapy device (Seqex), mean peripheral blood MDA decreased by 53.8% at the end of treatment (p=0.0002). One month later MDA increased relative to end-of-treatment but remained 15.6% lower than baseline (p=0.010).

Outcomes measured

  • Malondialdehyde (MDA) concentrations in peripheral blood
  • Oxidative stress / oxidative scale

Limitations

  • Background notes limited human evidence and conflicting animal/plant findings; no additional design details (e.g., control/sham, randomization, blinding) are provided in the abstract.
  • Exposure parameters (frequency, intensity, waveform) are described as complex/specific but not quantified in the abstract.
View raw extracted JSON
{
  "study_type": "other",
  "exposure": {
    "band": "ELF",
    "source": "magnetic therapy device (Seqex)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "treated using the Seqex cycle; outcomes measured before and after the cycle and one month later"
  },
  "population": "32 healthy volunteers (humans)",
  "sample_size": 32,
  "outcomes": [
    "Malondialdehyde (MDA) concentrations in peripheral blood",
    "Oxidative stress / oxidative scale"
  ],
  "main_findings": "In 32 healthy volunteers treated with an ELF magnetic therapy device (Seqex), mean peripheral blood MDA decreased by 53.8% at the end of treatment (p=0.0002). One month later MDA increased relative to end-of-treatment but remained 15.6% lower than baseline (p=0.010).",
  "effect_direction": "benefit",
  "limitations": [
    "Background notes limited human evidence and conflicting animal/plant findings; no additional design details (e.g., control/sham, randomization, blinding) are provided in the abstract.",
    "Exposure parameters (frequency, intensity, waveform) are described as complex/specific but not quantified in the abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF",
    "extremely low-frequency",
    "magnetic therapy",
    "Seqex",
    "oxidative stress",
    "free radicals",
    "malondialdehyde",
    "MDA",
    "ion cyclotron resonance",
    "Liboff hypothesis"
  ],
  "suggested_hubs": [
    {
      "slug": "elf-health-effects",
      "weight": 0.78,
      "reason": "Human study of extremely low-frequency magnetic field therapy and oxidative stress biomarker (MDA)."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/15368370802493271
PubMed: 19037782

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