Acute exposure to high-induction electromagnetic field affects activity of model peripheral sensory neurons.

Journal of cellular and molecular medicine · 2018 · Mixed · Low evidence

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MixedLow evidencePaper 4895

Short-term (<180 sec.) exposure of F11 cells to low-frequency electromagnetic field (LF-EMF) reduced calcium transients in response to bradykinin. LF-EMF also produced an immediate and reversible potentiating effect on neuronal spontaneous activity.

Study snapshot

PublicationJournal of cellular and molecular medicine · 2018

Study typein_vitro

Reported directionMixed

Evidence ratingLow

Abstract

Exposure to repetitive low-frequency electromagnetic field (LF-EMF) shows promise as a non-invasive approach to treat various sensory and neurological disorders. Despite considerable progress in the development of modern stimulation devices, there is a limited understanding of the mechanisms underlying their biological effects and potential targets at the cellular level. A significant impact of electromagnetic field on voltage-gated calcium channels and downstream signalling pathways has been convincingly demonstrated in many distinct cell types. However, evidence for clear effects on primary sensory neurons that particularly may be responsible for the analgesic actions of LF-EMF is still lacking. Here, we used F11 cells derived from dorsal root ganglia neurons as an in vitro model of peripheral sensory neurons and three different protocols of high-induction magnetic stimulation to determine the effects on chemical responsiveness and spontaneous activity. We show that short-term (<180 sec.) exposure of F11 cells to LF-EMF reduces calcium transients in response to bradykinin, a potent pain-producing inflammatory agent formed at sites of injury. Moreover, we characterize an immediate and reversible potentiating effect of LF-EMF on neuronal spontaneous activity. Our results provide new evidence that electromagnetic field may directly modulate the activity of sensory neurons and highlight the potential of sensory neuron-derived cell line as a tool for studying the underlying mechanisms at the cellular and molecular level.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionmixed

PopulationF11 cells derived from dorsal root ganglia neurons (in vitro model of peripheral sensory neurons)

Sample sizeNot supplied

ExposureLF · short-term (<180 sec.)

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Calcium transients in response to bradykinin
Neuronal spontaneous activity
Chemical responsiveness

Limitations

In vitro model (F11 cell line) rather than primary sensory neurons or in vivo outcomes
Exposure parameters (e.g., exact frequency, field strength/induction) not specified in the abstract
Sample size not reported in the abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "LF",
    "source": "magnetic stimulation",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "short-term (<180 sec.)"
  },
  "population": "F11 cells derived from dorsal root ganglia neurons (in vitro model of peripheral sensory neurons)",
  "sample_size": null,
  "outcomes": [
    "Calcium transients in response to bradykinin",
    "Neuronal spontaneous activity",
    "Chemical responsiveness"
  ],
  "main_findings": "Short-term (<180 sec.) exposure of F11 cells to low-frequency electromagnetic field (LF-EMF) reduced calcium transients in response to bradykinin. LF-EMF also produced an immediate and reversible potentiating effect on neuronal spontaneous activity.",
  "effect_direction": "mixed",
  "limitations": [
    "In vitro model (F11 cell line) rather than primary sensory neurons or in vivo outcomes",
    "Exposure parameters (e.g., exact frequency, field strength/induction) not specified in the abstract",
    "Sample size not reported in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "low-frequency electromagnetic field",
    "LF-EMF",
    "high-induction magnetic stimulation",
    "F11 cells",
    "dorsal root ganglia",
    "sensory neurons",
    "bradykinin",
    "calcium transients",
    "spontaneous activity"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1111/jcmm.13423
PubMed: 29210178

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