Chemoprotective action of lotus seedpod procyanidins on oxidative stress in mice induced by extremely low-frequency electromagnetic field exposure.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2016 · Mixed · Low evidence

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MixedLow evidencePaper 4835

In mice exposed to ELF-EMF (8 mT, 4 h/day for 28 days), oral lotus seedpod procyanidins (60, 90, or 120 mg/kg bw) significantly inhibited ELF-EMF-induced oxidative stress damage. LSPCs increased antioxidant enzyme activities (SOD, CAT, GSH-Px, GR, GST) and lo…

Study snapshot

PublicationBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2016

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

With the increasing use of electromagnetic technology, the effects of extremely low-frequency electromagnetic fields (ELF-EMF) on biological systems, central neurotransmitter systems, and human health have attracted extensive attention worldwide. In this study, lotus seedpod procyanidins (LSPCs) were evaluated for their protective effects on ELF-EMF induced oxidative stress injury in mice. Sixty male ICR mice were used for the experiment. The mice were randomly divided into five equal groups. The control group did not receive LSPCs or ELF-EMF but orally received normal saline. The ELF-EMF group received ELF-EMF exposure plus normal saline orally. The other three groups received ELF-EMF exposure plus LSPCs orally (60, 90, or 120mg kg(-1).bw, respectively). Each group exposed to ELF-EMF at 8 mT, 4h day(-1) for 28 consecutive days after administration daily of LSPCs or normal saline to mice for 15 consecutive days with the exception of the control group. Thereafter, blood and cerebral cortex of the mice were analyzed for antioxidant indices, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione-S-transferase (GST) and malondialdehyde (MDA). LSPCs administration at different doses significantly inhibited oxidative stress damage of mice induced by ELF-EMF. LSPCs treatment augmented SOD, CAT, GSH-Px, GR and GST activity. Furthermore, administration significantly lowered MDA level in LSPCs treatment groups LSPCs. All results indicated LSPCs can effectively prevent oxidative stress injury induced by ELF-EMF exposure, which may be related to its ability of scavenging free radicals and stimulating antioxidant enzyme activity.

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Study typeanimal

Effect directionmixed

PopulationMale ICR mice

Sample size60

ExposureELF · 8 mT, 4 h/day for 28 consecutive days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Oxidative stress/antioxidant indices in blood and cerebral cortex: SOD, CAT, GSH-Px, GR, GST, MDA

Limitations

Frequency of the ELF-EMF exposure not reported in the abstract.
No non-ELF-EMF + LSPCs-only group described (control received neither).
Outcomes are biochemical markers; no functional/clinical endpoints described in the abstract.
Only male mice used; generalizability limited.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "8 mT, 4 h/day for 28 consecutive days"
  },
  "population": "Male ICR mice",
  "sample_size": 60,
  "outcomes": [
    "Oxidative stress/antioxidant indices in blood and cerebral cortex: SOD, CAT, GSH-Px, GR, GST, MDA"
  ],
  "main_findings": "In mice exposed to ELF-EMF (8 mT, 4 h/day for 28 days), oral lotus seedpod procyanidins (60, 90, or 120 mg/kg bw) significantly inhibited ELF-EMF-induced oxidative stress damage. LSPCs increased antioxidant enzyme activities (SOD, CAT, GSH-Px, GR, GST) and lowered MDA levels compared with the ELF-EMF group.",
  "effect_direction": "mixed",
  "limitations": [
    "Frequency of the ELF-EMF exposure not reported in the abstract.",
    "No non-ELF-EMF + LSPCs-only group described (control received neither).",
    "Outcomes are biochemical markers; no functional/clinical endpoints described in the abstract.",
    "Only male mice used; generalizability limited."
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low-frequency electromagnetic field",
    "ELF-EMF",
    "oxidative stress",
    "lotus seedpod procyanidins",
    "LSPCs",
    "mice",
    "antioxidant enzymes",
    "SOD",
    "CAT",
    "GSH-Px",
    "GR",
    "GST",
    "MDA"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.biopha.2016.06.005
PubMed: 27470407

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