Protective Effect of 10-Hz, 1-mT Electromagnetic Field Exposure Against Hypoxia/Reoxygenation Injury in HK-2 Cells.

Biomedical and environmental sciences : BES · 2015 · Benefit · Low evidence

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BenefitLow evidencePaper 4787

In an in vitro hypoxia/reoxygenation injury model using HK-2 cells, 10 Hz/1 mT EMF exposure reversed the H/R-induced reduction in cell survival and reduced the H/R-associated increase in intracellular ROS.

Study snapshot

PublicationBiomedical and environmental sciences : BES · 2015

Study typein_vitro

Reported directionBenefit

Evidence ratingLow

Abstract

We investigated the protective effects of electromagnetic field (EMF) on the survival of the human renal proximal tubular cell line, HK-2, using an in vitro hypoxia/reoxygenation (H/R) injury model. The survival rate of cells cultured under H/R condition declined significantly, while the intracellular reactive oxygen species (ROS) levels markedly increased. The 10 Hz/1 mT EMF exposure reversed the H/R induced reduction in cell survival and induction of intracellular ROS. Our results suggest that 10 Hz/1 mT EMF exposure could inhibit H/R-induced cell death of HK-2 via suppression of intracellular ROS production and that this treatment might be clinically useful for the amelioration of renal ischemia/reperfusion injury.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionbenefit

PopulationHuman renal proximal tubular cell line (HK-2)

Sample sizeNot supplied

ExposureELF · 0.01 MHz

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Cell survival rate under hypoxia/reoxygenation (H/R) injury conditions
Intracellular reactive oxygen species (ROS) levels
H/R-induced cell death (inferred from survival/cell death wording)

Limitations

In vitro cell-line study; clinical relevance not established in the abstract
Exposure duration not reported in the abstract
Sample size and replication details not reported in the abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.01,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Human renal proximal tubular cell line (HK-2)",
  "sample_size": null,
  "outcomes": [
    "Cell survival rate under hypoxia/reoxygenation (H/R) injury conditions",
    "Intracellular reactive oxygen species (ROS) levels",
    "H/R-induced cell death (inferred from survival/cell death wording)"
  ],
  "main_findings": "In an in vitro hypoxia/reoxygenation injury model using HK-2 cells, 10 Hz/1 mT EMF exposure reversed the H/R-induced reduction in cell survival and reduced the H/R-associated increase in intracellular ROS.",
  "effect_direction": "benefit",
  "limitations": [
    "In vitro cell-line study; clinical relevance not established in the abstract",
    "Exposure duration not reported in the abstract",
    "Sample size and replication details not reported in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electromagnetic field",
    "ELF-EMF",
    "10 Hz",
    "1 mT",
    "HK-2 cells",
    "hypoxia/reoxygenation",
    "ischemia/reperfusion",
    "reactive oxygen species",
    "cell survival"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3967/bes2015.032
PubMed: 25800450

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