Influence of an extremely low frequency magnetic field (ELF-EMF) on antioxidative vitamin E properties in AT478 murine squamous cell carcinoma culture in vitro.

International journal of toxicology · 2010 · Benefit · Low evidence

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BenefitLow evidencePaper 4388

Vitamin E treatment increased antioxidant enzyme activity in an exposure-dependent manner. ELF-EMF alone or combined with vitamin E increased superoxide dismutase and glutathione peroxidase activities compared to control. ELF-EMF alters antioxidative activiti…

Study snapshot

PublicationInternational journal of toxicology · 2010

Study typein_vitro

Reported directionBenefit

Evidence ratingLow

Abstract

This study examines the effects of vitamin E and an extremely low frequency electromagnetic field (ELF-EMF) and their combination in different time intervals of exposure of vitamin E (tocopherol) on the AT478 murine squamous cell carcinoma line. This study provides insight into the influence of correlations between ELF-EMF and vitamin E supplementation on antioxidant enzyme activity in malignant cells in vitro. Following vitamin E treatment, activity of the antioxidant enzymes is increased in an exposure-dependent manner compared with the untreated group. Application of ELF-EMF alone or with vitamin E increases both superoxide dismutase isoenzymes and glutathione peroxidase activities in comparison to the control group. The results suggest that ELF-EMF alters antioxidative activities of vitamin E in AT478 tumor cells. This study confirms the role of vitamin E in decreasing susceptibility to lipid peroxidation in AT478 tumor cells.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionbenefit

PopulationAT478 murine squamous cell carcinoma cell line

Sample sizeNot supplied

ExposureELF

Evidence strengthLowConfidence: 30% · Peer reviewed: yes

Main findings

Outcomes measured

antioxidant enzyme activity
superoxide dismutase isoenzymes activity
glutathione peroxidase activity
lipid peroxidation susceptibility

Limitations

in vitro study, limiting direct applicability to humans
no information on exposure frequency or intensity
no sample size reported

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "AT478 murine squamous cell carcinoma cell line",
  "sample_size": null,
  "outcomes": [
    "antioxidant enzyme activity",
    "superoxide dismutase isoenzymes activity",
    "glutathione peroxidase activity",
    "lipid peroxidation susceptibility"
  ],
  "main_findings": "Vitamin E treatment increased antioxidant enzyme activity in an exposure-dependent manner. ELF-EMF alone or combined with vitamin E increased superoxide dismutase and glutathione peroxidase activities compared to control. ELF-EMF alters antioxidative activities of vitamin E in AT478 tumor cells and vitamin E decreases susceptibility to lipid peroxidation.",
  "effect_direction": "benefit",
  "limitations": [
    "in vitro study, limiting direct applicability to humans",
    "no information on exposure frequency or intensity",
    "no sample size reported"
  ],
  "evidence_strength": "low",
  "confidence": 0.3,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF-EMF",
    "vitamin E",
    "antioxidant enzymes",
    "murine squamous cell carcinoma",
    "in vitro",
    "oxidative stress"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1177/1091581809352011
PubMed: 20335516

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