Magnetic fields at extremely low-frequency (50 Hz, 0.8 mT) can induce the uptake of intracellular calcium levels in osteoblasts.

Biochemical and biophysical research communications · 2010 · Benefit · Low evidence

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BenefitLow evidencePaper 4381

Exposure to a 50 Hz, 0.8 mT extremely low-frequency magnetic field induced uptake of intracellular calcium in osteoblastic cells, demonstrating a specified window effect.

Study snapshot

PublicationBiochemical and biophysical research communications · 2010

Study typein_vitro

Reported directionBenefit

Evidence ratingLow

Abstract

Several studies have been undertaken to elucidate the effects of electromagnetic field (EMF) on intracellular calcium ([Ca(2+)](i)) in the past 20 years. However, still there were controversies of electromagnetic pollution within the scientific community. In this work, we studied the effects of alternative magnetic fields on intracellular calcium. Osteoblastic cells were used as a model both to test the hypothesis that extremely low-frequency (ELF) magnetic fields can alter the concentrations of the intracellular calcium, and to examine the 'window' effect predicted by our previous theoretical work. The outcome of this experiment demonstrated that 50 Hz, 0.8 mT magnetic field can induce the uptake of [Ca(2+)](i) in osteoblasts. The empirical evidences of the specified window effects of [Ca(2+)](i) in osteoblastic cells were reported for the first time in this work.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionbenefit

Populationosteoblastic cells (in vitro)

Sample sizeNot supplied

ExposureELF · 0.05 MHz

Evidence strengthLowConfidence: 50% · Peer reviewed: yes

Main findings

Exposure to a 50 Hz, 0.8 mT extremely low-frequency magnetic field induced uptake of intracellular calcium in osteoblastic cells, demonstrating a specified window effect.

Outcomes measured

intracellular calcium uptake

Limitations

in vitro study, limiting direct applicability to humans
sample size not specified
duration of exposure not detailed

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": null
  },
  "population": "osteoblastic cells (in vitro)",
  "sample_size": null,
  "outcomes": [
    "intracellular calcium uptake"
  ],
  "main_findings": "Exposure to a 50 Hz, 0.8 mT extremely low-frequency magnetic field induced uptake of intracellular calcium in osteoblastic cells, demonstrating a specified window effect.",
  "effect_direction": "benefit",
  "limitations": [
    "in vitro study, limiting direct applicability to humans",
    "sample size not specified",
    "duration of exposure not detailed"
  ],
  "evidence_strength": "low",
  "confidence": 0.5,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low-frequency magnetic fields",
    "intracellular calcium",
    "osteoblasts",
    "ELF",
    "magnetic field exposure",
    "calcium uptake"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.bbrc.2010.04.154
PubMed: 20438704

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