Modulation of Zebrafish Heart Rate by Alternating Magnetic Fields with Frequencies Close to Heart

IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology · 2024 · Mixed · Low evidence

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Study snapshot

PublicationIEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology · 2024

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Modulation of Zebrafish Heart Rate by Alternating Magnetic Fields with Frequencies Close to Heart Rhythm Krylov VV, Sizov DA, Machikhin AS, Guryleva AV, Tchougounov V, Burlakov AB. Modulation of Zebrafish Heart Rate by Alternating Magnetic Fields With Frequencies Close to Heart Rhythm. IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology. 2024. doi: 10.1109/JERM.2024.3397557. Abstract Extremely low-frequency magnetic fields (ELF-MF) up to 100 μT exhibit impacts on physiological processes, including heart function. The mechanisms underlying the influence of these fields on fish heart rates remain insufficiently explored. We assumed that the direct impact of ELF-MF with a frequency close to the heart rate could entrain oscillatory processes responsible for autonomously maintaining heart rhythm in zebrafish embryos. Embryos' heart rates ranged from 1.44 to 3 Hz depending on age, and ELF-MF with frequencies precisely matched, 10% higher, or lower than the heart rate were applied. Additionally, embryos experienced ELF-MF with amplitudes varying by an order of magnitude. Almost all tested ELF-MF induced an increased heart rate effect. This effect was the most pronounced when the exposure occurred earlier during ontogenesis. Fields with frequencies close to the heart rate did not entrain cardiac contractions in zebrafish embryos. A significant negative correlation between heart rate increase and ELF-MF frequency was observed for ELF-MF with amplitudes of 1.98– 3.2 μT and 46.8 μT but not 30 μT. Probable molecular mechanisms underlying these effects are discussed in terms of magnetic influence on radical pairs within biochemical oscillating processes. ieeexplore.ieee.org

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

Populationzebrafish embryos

Sample sizeNot supplied

ExposureELF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Zebrafish embryos were exposed to extremely low-frequency magnetic fields (ELF-MF) with frequencies matched to, 10% higher than, or lower than embryo heart rate (1.44–3 Hz) and with amplitudes varying by an order of magnitude (including 1.98–3.2 μT, 30 μT, and 46.8 μT). Almost all tested ELF-MF increased heart rate, with a more pronounced effect when exposure occurred earlier in ontogenesis. Frequencies close to heart rate did not entrain cardiac contractions; a significant negative correlation between heart rate increase and ELF-MF frequency was reported for some amplitudes (1.98–3.2 μT and 46.8 μT) but not 30 μT.

Outcomes measured

heart rate
cardiac contraction entrainment

Limitations

Sample size not reported in provided abstract/metadata
Exposure duration not reported in provided abstract/metadata
Details of experimental design (controls, blinding, randomization) not reported in provided abstract/metadata
Exact set of tested field amplitudes/frequencies not fully enumerated in provided abstract/metadata

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "alternating magnetic fields",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "zebrafish embryos",
  "sample_size": null,
  "outcomes": [
    "heart rate",
    "cardiac contraction entrainment"
  ],
  "main_findings": "Zebrafish embryos were exposed to extremely low-frequency magnetic fields (ELF-MF) with frequencies matched to, 10% higher than, or lower than embryo heart rate (1.44–3 Hz) and with amplitudes varying by an order of magnitude (including 1.98–3.2 μT, 30 μT, and 46.8 μT). Almost all tested ELF-MF increased heart rate, with a more pronounced effect when exposure occurred earlier in ontogenesis. Frequencies close to heart rate did not entrain cardiac contractions; a significant negative correlation between heart rate increase and ELF-MF frequency was reported for some amplitudes (1.98–3.2 μT and 46.8 μT) but not 30 μT.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Exposure duration not reported in provided abstract/metadata",
    "Details of experimental design (controls, blinding, randomization) not reported in provided abstract/metadata",
    "Exact set of tested field amplitudes/frequencies not fully enumerated in provided abstract/metadata"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low-frequency magnetic fields",
    "ELF-MF",
    "alternating magnetic fields",
    "zebrafish embryos",
    "heart rate",
    "ontogenesis",
    "μT",
    "entrainment",
    "radical pair"
  ],
  "suggested_hubs": [
    {
      "slug": "animal-studies",
      "weight": 0.9,
      "reason": "Experimental ELF magnetic-field exposure study in zebrafish embryos assessing physiological outcomes (heart rate)."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/jerm.2024.3397557
PubMed: Not supplied

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