RF Safe

Treatment of experimental inflammatory synovitis with continuous magnetic field.

Israel journal of medical sciences · 1996 · Benefit · Low evidence

← Research stream
BenefitLow evidencePaper 4200

Rats housed in a cage with a 3,800 Gauss magnet had lower histologic inflammatory scores than controls (3.4 ± 1.1 vs 6.8 ± 2.6; P = 0.002). Marked articular infiltrate was reported in 80% of controls versus small infiltration in 20% of treated rats.

Study snapshot

PublicationIsrael journal of medical sciences · 1996
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

The effect of a magnetic field on synovitis in rats was studied. Synovitis was induced by bilateral intraarticular injection of zymosan to the hind joints. One group of rats was held in a cage with a magnet of 3,800 Gauss on the bottom of the cage (treated), while another group was held in a cage without a magnet (control). Three weeks following intraarticular zymosan injection all rats were killed and the hind joints tissues were examined histologically. The pathologic process was noted and graded according to the involvement of various tissue components, number of inflammatory foci, and size of the lesion. The histologic findings of the tissues from the control group consisted of marked articular infiltrate, composed of lymphocytes and plasma cells with some histocytes in 80% of the animals. A small articular infiltration of the same nature was observed in 20% of the treated rats. The inflammatory score was 3.4 +/- 1.1 in the treated animals and 6.8 +/- 2.6 in the control group (P = 0.002). These data showed that synovitis and the inflammatory process are significantly suppressed by a magnetic field.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationRats with experimentally induced synovitis (zymosan intraarticular injection)
Sample sizeNot supplied
Exposurecontinuous exposure for 3 weeks (from zymosan injection until sacrifice)
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Rats housed in a cage with a 3,800 Gauss magnet had lower histologic inflammatory scores than controls (3.4 ± 1.1 vs 6.8 ± 2.6; P = 0.002). Marked articular infiltrate was reported in 80% of controls versus small infiltration in 20% of treated rats.

Outcomes measured

  • Histologic severity of synovitis/inflammation (graded pathology score)
  • Presence/extent of articular inflammatory infiltrate

Limitations

  • Sample size not reported in abstract
  • Randomization/blinding not described
  • Exposure characterization limited to magnet strength; field distribution at the animals not described
  • Only one time point assessed (3 weeks)
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "static magnet",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "continuous exposure for 3 weeks (from zymosan injection until sacrifice)"
  },
  "population": "Rats with experimentally induced synovitis (zymosan intraarticular injection)",
  "sample_size": null,
  "outcomes": [
    "Histologic severity of synovitis/inflammation (graded pathology score)",
    "Presence/extent of articular inflammatory infiltrate"
  ],
  "main_findings": "Rats housed in a cage with a 3,800 Gauss magnet had lower histologic inflammatory scores than controls (3.4 ± 1.1 vs 6.8 ± 2.6; P = 0.002). Marked articular infiltrate was reported in 80% of controls versus small infiltration in 20% of treated rats.",
  "effect_direction": "benefit",
  "limitations": [
    "Sample size not reported in abstract",
    "Randomization/blinding not described",
    "Exposure characterization limited to magnet strength; field distribution at the animals not described",
    "Only one time point assessed (3 weeks)"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "magnet",
    "synovitis",
    "inflammation",
    "zymosan",
    "rat model",
    "histology"
  ],
  "suggested_hubs": []
}
AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 9007153

Read the original paper →

Related papers

← Back to the Research Library