[Effects of high-frequency electromagnetic field on morphology of hippocampal cells in female rats].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases · 2010 · Harm · Moderate evidence

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HarmModerate evidencePaper 4353

Short-term exposure (3 days) to 30 MHz HF-EMF at 25-1600 V/m showed no significant effect on hippocampal cell apoptosis or morphology. Chronic exposure (56 days) at higher intensities (400 and 1600 V/m) significantly increased apoptotic rates and caused abnor…

Study snapshot

PublicationZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases · 2010

Study typerandomized_trial

Reported directionHarm

Evidence ratingModerate

Abstract

OBJECTIVE: To analyze the effects of high-frequency electromagnetic field (HF-EMF, 30 MHz, 0-1600 V/m) on the apoptosis and ultramicrostructure of the hippocamp and demonstrate the cytotoxicity of hippocamp. METHODS: 120 Wistar female adult rats were randomly divided into ten groups based on body weight with different levels of 30 MHz electromagnetic field (0, 25, 100, 400, 1600 V/m) for eight hours daily. Five group rats were irradiated for three days. The other five group rats were irradiated for fifty-six days. Weekly the rats were continuously exposed five days. The apoptotic rate of the hippocamp was detected with TUNEL System. Meanwhile, the ultramicrostructure was observed with the transmission electron microscope. RESULTS: (1) There was no significant difference on the apoptotic rate and pathological change of the hippocamp cell between the exposure and the control groups through short term experiment (P > 0.05). (2) The apoptotic rate of the granulocyte on the DG campus of the hippocamp in the 400 V/m group and the 1600 V/m group (0.165% +/- 0.049%, 0.189% +/- 0.049% respectively) were increased significantly (P < 0.01) through inferior chronic experiment compared with the control group (0.052% +/- 0.016%). Along with the increase of radiation dose, the ultramicrostructure of the neuron cell appeared more abnormal cells. Especially there were marked change on the neuron in the 1600 V/m group. CONCLUSIONS: There is no association between cell apoptotic rate of the hippocamp and short period exposure to HF-EMF (30 MHz, 25-1600 V/m). However inferior chronic exposures to HF-EMF might induce the cytotoxicity, especially in the high dose exposure (1600 V/m) under our experiment.

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Study typerandomized_trial

Effect directionharm

Population120 Wistar female adult rats

Sample size120

Exposurehigh-frequency · 30 MHz · 3 days or 56 days, 8 hours daily, 5 days per week

Evidence strengthModerateConfidence: 70% · Peer reviewed: yes

Main findings

Outcomes measured

apoptotic rate of hippocamp cells
ultramicrostructure of hippocamp neurons

Limitations

Study conducted in rats, limiting direct human applicability
Exposure intensity measured in V/m without SAR values
Only female rats studied
No behavioral or functional outcomes assessed

View raw extracted JSON

{
  "study_type": "randomized_trial",
  "exposure": {
    "band": "high-frequency",
    "source": null,
    "frequency_mhz": 30,
    "sar_wkg": null,
    "duration": "3 days or 56 days, 8 hours daily, 5 days per week"
  },
  "population": "120 Wistar female adult rats",
  "sample_size": 120,
  "outcomes": [
    "apoptotic rate of hippocamp cells",
    "ultramicrostructure of hippocamp neurons"
  ],
  "main_findings": "Short-term exposure (3 days) to 30 MHz HF-EMF at 25-1600 V/m showed no significant effect on hippocampal cell apoptosis or morphology. Chronic exposure (56 days) at higher intensities (400 and 1600 V/m) significantly increased apoptotic rates and caused abnormal neuronal ultrastructure, especially at 1600 V/m.",
  "effect_direction": "harm",
  "limitations": [
    "Study conducted in rats, limiting direct human applicability",
    "Exposure intensity measured in V/m without SAR values",
    "Only female rats studied",
    "No behavioral or functional outcomes assessed"
  ],
  "evidence_strength": "moderate",
  "confidence": 0.7,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "high-frequency electromagnetic field",
    "hippocampus",
    "apoptosis",
    "ultrastructure",
    "rats",
    "cytotoxicity"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.8,
      "reason": "Study of high-frequency EMF exposure effects relevant to occupational settings"
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 21033149

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