Molecular mechanism of effect of rotating constant magnetic field on organisms.

Science in China. Series C, Life sciences · 2001 · Benefit · Very low evidence

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BenefitVery low evidencePaper 3852

Study snapshot

PublicationScience in China. Series C, Life sciences · 2001

Study typeanimal

Reported directionBenefit

Evidence ratingVery low

Abstract

The effect of RCMF-magnetic therapy apparatus on signal substances was studied. The radioimmunoassay (RIA) suggested that the magnetic field increased beta-endorphin markedly in plasma. ELISA indicated that the magnetic field inhibited vomiting reaction induced by chemotherapy drug, with reversible decrease of serotonin (5-HT) level in brains, small intestine tissue and serum. Furthermore, the bioeffect of magnetic fields on 5-HT level presented a typical window effect and post-effect, and the inhibitory effect of magnetic field on the emesis was parallel to the decrease level of 5-HT. This result implied that the decrease of 5-HT might be the basis of rotating constant magnetic field (RCMF) inhibiting drug-induced emesis. The nitric acid reductase-spectrophotometry and nicotinamide adenine dinucleotide-diaphorase/arginine-vasopressin (AVP) cytochemistry technique showed that the magnetic field induced nitric oxide (NO) increase in hypothalamus and the high NO(A) level lasted for 3 hours. The results suggested that NO(A) increases after the treatment of the magnetic field in hypothalamus, which may result from strong expression of NO-ergic neuron in paraventricular hypothalamic nucleus (PVN), periventricular hypothalamic nucleus (PEN) and supraoptic nucleus (SON). The coexistence of NO and AVP may play an important role in the regulation of endocrine and neuroendocrine by the magnetic field. And our data also confirmed that the magnetic field increased the content of NO so strongly that high NO level lasted for 3 hours, also made neuropeptide Y (NPY) cell in medulla stained heavily.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

Populationorganisms (animal model not specified)

Sample sizeNot supplied

ExposureELF

Evidence strengthVery lowConfidence: 66% · Peer reviewed: yes

Main findings

Radioimmunoassay suggested the rotating constant magnetic field increased plasma beta-endorphin markedly. ELISA indicated the magnetic field inhibited chemotherapy drug-induced vomiting, accompanied by a reversible decrease of serotonin (5-HT) in brain, small intestine tissue, and serum; a window effect and post-effect were reported, and emesis inhibition was described as parallel to decreased 5-HT. Spectrophotometry/cytochemistry methods indicated increased hypothalamic nitric oxide (NO) with elevated levels lasting about 3 hours, with suggested strong expression of NO-ergic neurons in PVN, PEN, and SON; NPY cells in medulla were reported to stain heavily.

Outcomes measured

Plasma beta-endorphin
Chemotherapy drug-induced vomiting (emesis)
Serotonin (5-HT) levels in brain, small intestine tissue, and serum
Nitric oxide (NO) levels in hypothalamus and duration of elevation
NO-ergic neuron expression in PVN, PEN, SON
Arginine-vasopressin (AVP) coexistence with NO
Neuropeptide Y (NPY) staining in medulla

Limitations

Study design details (species, randomization, controls) not described in the abstract
Exposure parameters (field strength, rotation rate, duration) not reported
Sample size not reported
Outcomes rely on biomarker changes and inferred mechanisms; clinical relevance to humans not established in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "rotating constant magnetic field (RCMF) magnetic therapy apparatus",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "organisms (animal model not specified)",
  "sample_size": null,
  "outcomes": [
    "Plasma beta-endorphin",
    "Chemotherapy drug-induced vomiting (emesis)",
    "Serotonin (5-HT) levels in brain, small intestine tissue, and serum",
    "Nitric oxide (NO) levels in hypothalamus and duration of elevation",
    "NO-ergic neuron expression in PVN, PEN, SON",
    "Arginine-vasopressin (AVP) coexistence with NO",
    "Neuropeptide Y (NPY) staining in medulla"
  ],
  "main_findings": "Radioimmunoassay suggested the rotating constant magnetic field increased plasma beta-endorphin markedly. ELISA indicated the magnetic field inhibited chemotherapy drug-induced vomiting, accompanied by a reversible decrease of serotonin (5-HT) in brain, small intestine tissue, and serum; a window effect and post-effect were reported, and emesis inhibition was described as parallel to decreased 5-HT. Spectrophotometry/cytochemistry methods indicated increased hypothalamic nitric oxide (NO) with elevated levels lasting about 3 hours, with suggested strong expression of NO-ergic neurons in PVN, PEN, and SON; NPY cells in medulla were reported to stain heavily.",
  "effect_direction": "benefit",
  "limitations": [
    "Study design details (species, randomization, controls) not described in the abstract",
    "Exposure parameters (field strength, rotation rate, duration) not reported",
    "Sample size not reported",
    "Outcomes rely on biomarker changes and inferred mechanisms; clinical relevance to humans not established in abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "rotating constant magnetic field",
    "RCMF",
    "magnetic therapy",
    "beta-endorphin",
    "serotonin",
    "5-HT",
    "emesis",
    "chemotherapy-induced vomiting",
    "nitric oxide",
    "hypothalamus",
    "AVP",
    "NPY",
    "window effect",
    "post-effect"
  ],
  "suggested_hubs": [
    {
      "slug": "magnet-therapy",
      "weight": 0.78,
      "reason": "Study evaluates biological effects of a rotating constant magnetic field from a magnetic therapy apparatus."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/bf02882398
PubMed: 18726401

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