[Effect of handportable mobiletelephone microwave radiation on rat central neuron apoptosis].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases · 2003 · Mixed · Low evidence

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MixedLow evidencePaper 3725

In intact rats, the radiation group did not differ significantly from control on TUNEL positivity or Bax/Bcl-2-related measures. In rats with cranial defect (decranium + radiation), TUNEL positive rate and Bax and Bcl-2 positive cell numbers were higher than …

Study snapshot

PublicationZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases · 2003

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

OBJECTIVE: To investigate the effect of handportable mobiletelephone microwave radiation on rat central nervous system by setting up rat model. METHODS: 80 healthy male SD rats (weighed about 200 g) were divided into 4 groups at random: control, radiation, decranium, decranium + radiation. TUNEL method was adopted used to detect the apoptosis of neurons after irradiation, then immunohistochemistry was used to detect Bcl-2, Bax expression in all brain tissue. RESULTS: TUNEL positive rate, Bax and Bcl-2 positive cell numbers could be found in decranium + radiation group [(26.45 +/- 9.27)%, (23.5 +/- 3.58), (11.1 +/- 2.55) respectively]. There were significant differences among control [(9.59 +/- 2.55)%, 14.2 +/- 2.46, 7.0 +/- 1.14 respectively], decranium group [(9.52 +/- 1.93)%, 15.5 +/- 1.77, 7.4 +/- 1.76], radiation group [(10.04 +/- 3.62)%, 15.9 +/- 2.02, 7.2 +/- 1.07] (P < 0.01). But the difference was not found in the ratio of Bax to Bcl-2. CONCLUSION: Microwave radiation did not affect the intact rat, but did promote the occurrence of neuron apoptosis in cranial defect rat. Bax, Bcl-2 gene participated in regulation of apoptosis. The intact cranium may be an important factor to protect the neurons against handportable mobiletelephone microwave radiation to some extent.

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Study typeanimal

Effect directionmixed

PopulationMale SD rats (~200 g)

Sample size80

Exposuremicrowave

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Neuron apoptosis (TUNEL positive rate)
Bax expression (immunohistochemistry)
Bcl-2 expression (immunohistochemistry)
Bax/Bcl-2 ratio

Limitations

No exposure parameters reported (e.g., frequency, SAR, duration)
Animal model with cranial defect may limit generalizability to intact organisms
Outcome assessment limited to TUNEL and immunohistochemistry markers reported in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": "handportable mobiletelephone",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Male SD rats (~200 g)",
  "sample_size": 80,
  "outcomes": [
    "Neuron apoptosis (TUNEL positive rate)",
    "Bax expression (immunohistochemistry)",
    "Bcl-2 expression (immunohistochemistry)",
    "Bax/Bcl-2 ratio"
  ],
  "main_findings": "In intact rats, the radiation group did not differ significantly from control on TUNEL positivity or Bax/Bcl-2-related measures. In rats with cranial defect (decranium + radiation), TUNEL positive rate and Bax and Bcl-2 positive cell numbers were higher than in control, decranium-only, and radiation-only groups (P<0.01), while the Bax/Bcl-2 ratio did not differ.",
  "effect_direction": "mixed",
  "limitations": [
    "No exposure parameters reported (e.g., frequency, SAR, duration)",
    "Animal model with cranial defect may limit generalizability to intact organisms",
    "Outcome assessment limited to TUNEL and immunohistochemistry markers reported in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "mobile phone",
    "microwave radiation",
    "rat",
    "central nervous system",
    "neuron apoptosis",
    "TUNEL",
    "Bax",
    "Bcl-2",
    "cranial defect"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones",
      "weight": 0.9,
      "reason": "Exposure source is handportable mobile telephone microwave radiation."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 14761573

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