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Progression of arteriovenous bypass restenosis in mice exposed to a 50 Hz magnetic field.

Cell stress & chaperones · 2003 · Mixed · Low evidence

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MixedLow evidencePaper 3702

Mice exposed to a high-intensity 50 Hz magnetic field for 1 week had significantly smaller neointima formation than null-field controls, but this difference was not observed after 2 or 3 weeks of exposure. No differences were found between exposed and control…

Study snapshot

PublicationCell stress & chaperones · 2003
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

The controversy over whether magnetic fields (MF) produced by electrical wiring and appliances contribute to diseases such as cancer has been debated in the literature for more than 2 decades. These extremely low frequency fields at 50 or 60 Hz are omnipresent in the industrialized world and have been linked to various forms of cancer by epidemiological studies. Little has been published investigating any possible role of MF and cardiovascular disease, and this is the first study looking specifically at the effect of exposure to high-intensity MF on the development and progression of restenosis. A mouse arteriovenous bypass model was used, and mice were exposed to MF for periods of 1, 2, or 3 weeks. Neointima formation, infiltration of mononuclear cells, and heat shock protein 60 expression were all studied at the conclusion of the exposure regimen. Animals exposed to the MF for 1 week showed significantly smaller neointima formation compared with control mice exposed to a null field, although this difference was not observed in mice exposed for 2 or 3 weeks. No difference was found between mice exposed to MF and controls in any of the other parameters investigated.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationMice in an arteriovenous bypass model
Sample sizeNot supplied
ExposureELF · 0.05 MHz · 1, 2, or 3 weeks
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Mice exposed to a high-intensity 50 Hz magnetic field for 1 week had significantly smaller neointima formation than null-field controls, but this difference was not observed after 2 or 3 weeks of exposure. No differences were found between exposed and control animals for mononuclear cell infiltration or heat shock protein 60 expression.

Outcomes measured

  • Neointima formation (restenosis progression)
  • Infiltration of mononuclear cells
  • Heat shock protein 60 expression

Limitations

  • Magnetic field intensity not reported in the abstract
  • Sample size not reported in the abstract
  • Details of exposure setup and dosimetry not reported in the abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "1, 2, or 3 weeks"
  },
  "population": "Mice in an arteriovenous bypass model",
  "sample_size": null,
  "outcomes": [
    "Neointima formation (restenosis progression)",
    "Infiltration of mononuclear cells",
    "Heat shock protein 60 expression"
  ],
  "main_findings": "Mice exposed to a high-intensity 50 Hz magnetic field for 1 week had significantly smaller neointima formation than null-field controls, but this difference was not observed after 2 or 3 weeks of exposure. No differences were found between exposed and control animals for mononuclear cell infiltration or heat shock protein 60 expression.",
  "effect_direction": "mixed",
  "limitations": [
    "Magnetic field intensity not reported in the abstract",
    "Sample size not reported in the abstract",
    "Details of exposure setup and dosimetry not reported in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "50 Hz",
    "extremely low frequency",
    "magnetic field",
    "mouse model",
    "arteriovenous bypass",
    "restenosis",
    "neointima",
    "mononuclear cells",
    "HSP60"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.2,
      "reason": "Study concerns high-intensity 50 Hz magnetic field exposure, relevant to ELF exposure contexts (though setting not specified)."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1379/1466-1268(2003)008<0373:poabri>2.0.co;2
PubMed: 15115289

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