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Feasibility study for focusing electric fields to mediate in vitro drug and gene delivery.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2006 · Benefit · Very low evidence

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BenefitVery low evidencePaper 3455

The paper reports modeling and an experimental in vitro proof-of-concept method to direct and focus pulsed electric fields to concentrate drug or gene uptake at a desired site. The in vitro results are described as consistent with simulation models, with pote…

Study snapshot

PublicationConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2006
Study typeother
Reported directionBenefit
Evidence ratingVery low

Abstract

Electric field mediated drug and gene delivery is a novel method that uses pulsed electric fields to improve permeability of cell membranes and therefore desired agent uptake by tissues. In this paper, we describe the modeling and experimental proof of concept of a method to direct electric fields to subsequently focus drug or gene uptake at a desired site. The in vitro experimental results presented are consistent with simulation models and could be scaled into different in vivo applications that can concentrate the effects of electroporation and overcome several problems related to localized effects near the electrodes.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother
Effect directionbenefit
PopulationNot supplied
Sample sizeNot supplied
ExposureNot supplied
Evidence strengthVery lowConfidence: 66% · Peer reviewed: unknown

Main findings

The paper reports modeling and an experimental in vitro proof-of-concept method to direct and focus pulsed electric fields to concentrate drug or gene uptake at a desired site. The in vitro results are described as consistent with simulation models, with potential scalability to in vivo applications to reduce localized effects near electrodes.

Outcomes measured

  • cell membrane permeability
  • in vitro drug uptake
  • in vitro gene uptake
  • localized/focused electroporation effects

Limitations

  • Conference proceedings format; limited methodological details in abstract
  • In vitro proof-of-concept; in vivo effectiveness not demonstrated in abstract
  • No quantitative exposure parameters (e.g., field strength, pulse characteristics) reported in abstract
  • Sample size not reported in abstract
View raw extracted JSON
{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "pulsed electric fields (electroporation)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "cell membrane permeability",
    "in vitro drug uptake",
    "in vitro gene uptake",
    "localized/focused electroporation effects"
  ],
  "main_findings": "The paper reports modeling and an experimental in vitro proof-of-concept method to direct and focus pulsed electric fields to concentrate drug or gene uptake at a desired site. The in vitro results are described as consistent with simulation models, with potential scalability to in vivo applications to reduce localized effects near electrodes.",
  "effect_direction": "benefit",
  "limitations": [
    "Conference proceedings format; limited methodological details in abstract",
    "In vitro proof-of-concept; in vivo effectiveness not demonstrated in abstract",
    "No quantitative exposure parameters (e.g., field strength, pulse characteristics) reported in abstract",
    "Sample size not reported in abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.66,
  "peer_reviewed_likely": "unknown",
  "keywords": [
    "pulsed electric fields",
    "electroporation",
    "drug delivery",
    "gene delivery",
    "in vitro",
    "electric field focusing",
    "modeling",
    "proof of concept"
  ],
  "suggested_hubs": []
}
AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/iembs.2006.259865
PubMed: 17947153

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