Electric field analysis of breast tumor cells.

International journal of breast cancer · 2011 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 3252

Using a tissue model simulated in MAXWELL 3D, the authors report that tumor tissue had lower electric field strength than normal cells. They suggest this lower field strength may make tumor tissue susceptible to electrical-pulse-mediated drug delivery and att…

Study snapshot

PublicationInternational journal of breast cancer · 2011

Study typeengineering

Reported directionUnclear

Evidence ratingInsufficient

Abstract

An attractive alternative treatment for malignant tumors that are refractive to conventional therapies, such as surgery, radiation, and chemotherapy, is electrical-pulse-mediated drug delivery. Electric field distribution of tissue/tumor is important for effective treatment of tissues. This paper deals with the electric field distribution study of a tissue model using MAXWELL 3D Simulator. Our results indicate that tumor tissue had lower electric field strength compared to normal cells, which makes them susceptible to electrical-pulse-mediated drug delivery. This difference could be due to the altered properties of tumor cells compared to normal cells, and our results corroborate this.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeengineering

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Electric field distribution/strength in tumor vs normal tissue model
Susceptibility to electrical-pulse-mediated drug delivery (inferred from field strength differences)

Limitations

Simulation/modeling study; no in vivo or clinical outcomes reported in abstract
No quantitative exposure parameters (e.g., pulse characteristics, field magnitude) provided in abstract
Sample size and model details not described in abstract

View raw extracted JSON

{
  "study_type": "engineering",
  "exposure": {
    "band": null,
    "source": "electrical-pulse-mediated drug delivery",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Electric field distribution/strength in tumor vs normal tissue model",
    "Susceptibility to electrical-pulse-mediated drug delivery (inferred from field strength differences)"
  ],
  "main_findings": "Using a tissue model simulated in MAXWELL 3D, the authors report that tumor tissue had lower electric field strength than normal cells. They suggest this lower field strength may make tumor tissue susceptible to electrical-pulse-mediated drug delivery and attribute differences to altered tumor-cell properties.",
  "effect_direction": "unclear",
  "limitations": [
    "Simulation/modeling study; no in vivo or clinical outcomes reported in abstract",
    "No quantitative exposure parameters (e.g., pulse characteristics, field magnitude) provided in abstract",
    "Sample size and model details not described in abstract"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electric field distribution",
    "tumor tissue",
    "breast tumor cells",
    "electrical pulses",
    "drug delivery",
    "MAXWELL 3D Simulator",
    "tissue model"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.4061/2011/235926
PubMed: 22295214

Read the original paper →

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