The movement of actin-myosin biomolecular linear motor under AC electric fields: an experimental study.

Journal of colloid and interface science · 2013 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 3172

In an AC electric field, F-actin movement on a myosin-coated substrate became aligned and moved perpendicularly toward electrode edges. The aligned movement increased with electric field strength and was frequency-dependent; velocity measurements indicated an…

Study snapshot

PublicationJournal of colloid and interface science · 2013

Study typein_vitro

Reported directionUnclear

Evidence ratingInsufficient

Abstract

The role of actin-myosin as a biomolecular linear motor is considered a transport system at nanoscale because of their size, efficiency and functionality. To utilize the ability to transport, it is essential to control the random movement of actin filaments (F-actin) on myosin coated substrate. In the presence of an alternating current (AC) electric field, the direction of F-actin movement is regulated by electro-orientation torque and, as a result, its movement is perpendicularly toward the electrode edges. Our data confirm such aligned movement is proportional to the strength of applied electric field. Interestingly, the aligned movement is found frequency-dependent and the electrothermal effect is observed by means of the velocity measurement of aligned F-actin movement. The findings in this study may provide constructive information for manipulating actin-myosin nanotransport system to build functional nanodevices in future work.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Direction/alignment of F-actin movement on myosin-coated substrate
Velocity of aligned F-actin movement
Electro-orientation torque effects
Frequency dependence of aligned movement
Electrothermal effect inferred from velocity measurements

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": null,
    "source": "AC electric field",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Direction/alignment of F-actin movement on myosin-coated substrate",
    "Velocity of aligned F-actin movement",
    "Electro-orientation torque effects",
    "Frequency dependence of aligned movement",
    "Electrothermal effect inferred from velocity measurements"
  ],
  "main_findings": "In an AC electric field, F-actin movement on a myosin-coated substrate became aligned and moved perpendicularly toward electrode edges. The aligned movement increased with electric field strength and was frequency-dependent; velocity measurements indicated an electrothermal effect.",
  "effect_direction": "unclear",
  "limitations": [],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "actin",
    "myosin",
    "F-actin",
    "biomolecular motor",
    "AC electric field",
    "electro-orientation torque",
    "frequency dependence",
    "electrothermal effect",
    "nanotransport",
    "nanodevices"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.jcis.2012.11.072
PubMed: 23374431

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