Increased Radioresistance to Lethal Doses of Gamma Rays in Mice and Rats after Exposure to Microwave Radiation Emitted by a GSM Mobile Phone Simulator.

Dose-response : a publication of International Hormesis Society · 2013 · Benefit · Low evidence

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BenefitLow evidencePaper 3132

Study snapshot

PublicationDose-response : a publication of International Hormesis Society · 2013

Study typeanimal

Reported directionBenefit

Evidence ratingLow

Abstract

The aim of this study was to investigate the effect of pre-irradiation with microwaves on the induction of radioadaptive response. In the 1(st) phase of the study, 110 male mice were divided into 8 groups. The animals in these groups were exposed/sham-exposed to microwave, low dose rate gamma or both for 5 days. On day six, the animals were exposed to a lethal dose (LD). In the 2(nd) phase, 30 male rats were divided into 2 groups of 15 animals. The 1(st) group received microwave exposure. The 2(nd) group (controls) received the same LD but there was no treatment before the LD. On day 5, all animals were whole-body irradiated with the LD. Statistically significant differences between the survival rate of the mice only exposed to lethal dose of gamma radiation before irradiation with a lethal dose of gamma radiation with those of the animals pre-exposed to either microwave (p=0.02), low dose rate gamma (p=0.001) or both of these physical adapting doses (p=0.003) were observed. Likewise, a statistically significant difference between survival rates of the rats in control and test groups was observed. Altogether, these experiments showed that exposure to microwave radiation may induce a significant survival adaptive response.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationMale mice and male rats

Sample size140

Exposuremicrowave · 5 days (pre-irradiation); lethal dose gamma on day 6 (mice) / day 5 (rats)

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In mice, survival after a lethal dose of gamma radiation differed significantly between animals receiving only the lethal dose and those pre-exposed to microwave (p=0.02), low dose rate gamma (p=0.001), or both (p=0.003). In rats, survival rates also differed significantly between microwave-pre-exposed animals and controls receiving only the lethal dose. The authors conclude that microwave exposure may induce a significant survival adaptive response.

Outcomes measured

Survival rate after lethal dose (LD) gamma irradiation
Radioadaptive response / radioresistance to gamma rays

Limitations

No microwave exposure parameters reported in abstract (e.g., frequency, SAR, power density).
Outcome limited to survival after lethal gamma irradiation; broader health endpoints not described.
Details on randomization/blinding and housing/handling controls not provided in abstract.
Statistical effect sizes and absolute survival numbers not reported in abstract.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": "GSM mobile phone simulator",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "5 days (pre-irradiation); lethal dose gamma on day 6 (mice) / day 5 (rats)"
  },
  "population": "Male mice and male rats",
  "sample_size": 140,
  "outcomes": [
    "Survival rate after lethal dose (LD) gamma irradiation",
    "Radioadaptive response / radioresistance to gamma rays"
  ],
  "main_findings": "In mice, survival after a lethal dose of gamma radiation differed significantly between animals receiving only the lethal dose and those pre-exposed to microwave (p=0.02), low dose rate gamma (p=0.001), or both (p=0.003). In rats, survival rates also differed significantly between microwave-pre-exposed animals and controls receiving only the lethal dose. The authors conclude that microwave exposure may induce a significant survival adaptive response.",
  "effect_direction": "benefit",
  "limitations": [
    "No microwave exposure parameters reported in abstract (e.g., frequency, SAR, power density).",
    "Outcome limited to survival after lethal gamma irradiation; broader health endpoints not described.",
    "Details on randomization/blinding and housing/handling controls not provided in abstract.",
    "Statistical effect sizes and absolute survival numbers not reported in abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "GSM",
    "mobile phone simulator",
    "radioadaptive response",
    "radioresistance",
    "gamma rays",
    "survival",
    "mice",
    "rats",
    "pre-irradiation"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones-rf",
      "weight": 0.86,
      "reason": "Microwave exposure emitted by a GSM mobile phone simulator."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.2203/dose-response.12-010.mortazavi
PubMed: 23930107

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