Pre-Exposure to Radiofrequency Electromagnetic Fields and Induction of Radioadaptive Response in Rats Irradiated with High Doses of X-Rays

2022 · Mixed · Low evidence

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MixedLow evidencePaper 653

In survival analysis, survival rates in all exposed groups (8 Gy X-rays, mobile phone+8 Gy, Wi-Fi+8 Gy) were significantly lower than control and RF-only groups, and survival differences among the three irradiated groups were not statistically significant. Fo…

Study snapshot

Publicationmanual · 2022

Study typecase_control

Reported directionMixed

Evidence ratingLow

Abstract

Pre-Exposure to Radiofrequency Electromagnetic Fields and Induction of Radioadaptive Response in Rats Irradiated with High Doses of X-Rays Borzoueisileh S, Shabestani Monfared A, Mortazavi SMJ, Zabihi E, Pouramir M, Niksirat F, Seyfizadeh N, Shafiee M. Pre-Exposure to Radiofrequency Electromagnetic Fields and Induction of Radioadaptive Response in Rats Irradiated with High Doses of X-Rays. J Biomed Phys Eng. 2022 Oct 1;12(5):505-512. doi: 10.31661/jbpe.v0i0.1271. Abstract Background: Some evidence shows that a pre-exposure to RF can mitigate the effects of subsequent exposures to high doses of ionizing radiation. Objective: We aimed to assess the effect of a pre-exposure to non-ionizing RF radiation on survival, weight changes, food consumption, and water intake of lethally irradiated rats. Material and methods: In this case-control study, we used a commercial mobile phone (GSM, 900/1800 MHz) as well as a 2.4 GHz Wi-Fi router as the sources of pre-exposure to RF radiation. Forty-eight rats were randomly divided into six groups of control, "8 Gy X-rays", mobile phone, "mobile phone+8 Gy", Wi-Fi, and "Wi-Fi+8 Gy". Then, the survival fraction, weight loss, water, and food consumption changes were compared in different groups. Results: The survival analysis indicated that the survival rates in all of the exposed animals ("8 Gy X-rays", "mobile phone+8 Gy", "Wi-Fi+8 Gy") were significantly lower than the control, "Wi-Fi", and "mobile phone" groups. The changes in survival rates of "mobile+8 Gy", "Wi-Fi+8 Gy", and 8 Gy alone were not statistically significant. However, food and water intake were significantly affected by exposure to both RF pre-exposures and exposure to high dose ionizing radiation. Conclusion: To the best of our knowledge, the existence of a dose window for the induction of AR [adaptive response] can be the cause of the lack of AR in our experiment. Our findings confirm that in a similar pattern with the adaptive responses induced by pre-exposure to ionizing radiation, the induction of adaptive response by RF-pre-exposures requires a minimum level of damage to trigger adaptive phenomena. Open access paper: ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typecase_control

Effect directionmixed

PopulationRats

Sample size48

ExposureRF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Survival fraction/rate
Weight changes/weight loss
Food consumption/intake
Water intake

Limitations

RF exposure duration not reported in abstract
RF exposure level/SAR not reported in abstract
Details of randomization and blinding not described in abstract
Animal study; generalizability to humans is uncertain

View raw extracted JSON

{
  "study_type": "case_control",
  "exposure": {
    "band": "RF",
    "source": "mobile phone; wi-fi router",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Rats",
  "sample_size": 48,
  "outcomes": [
    "Survival fraction/rate",
    "Weight changes/weight loss",
    "Food consumption/intake",
    "Water intake"
  ],
  "main_findings": "In survival analysis, survival rates in all exposed groups (8 Gy X-rays, mobile phone+8 Gy, Wi-Fi+8 Gy) were significantly lower than control and RF-only groups, and survival differences among the three irradiated groups were not statistically significant. Food and water intake were significantly affected by both RF pre-exposures and high-dose ionizing radiation.",
  "effect_direction": "mixed",
  "limitations": [
    "RF exposure duration not reported in abstract",
    "RF exposure level/SAR not reported in abstract",
    "Details of randomization and blinding not described in abstract",
    "Animal study; generalizability to humans is uncertain"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "radiofrequency",
    "RF",
    "GSM",
    "900 MHz",
    "1800 MHz",
    "Wi-Fi",
    "2.4 GHz",
    "radioadaptive response",
    "adaptive response",
    "X-rays",
    "8 Gy",
    "rats",
    "survival",
    "food intake",
    "water intake",
    "weight loss"
  ],
  "suggested_hubs": [
    {
      "slug": "school-wi-fi",
      "weight": 0.35,
      "reason": "Uses a 2.4 GHz Wi-Fi router as an RF exposure source (though in an animal experiment)."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.31661/jbpe.v0i0.1271
PubMed: Not supplied

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