RF Safe

Microwave radiation induced oxidative stress, cognitive impairment and inflammation in brain of Fischer rats.

Indian journal of experimental biology · 2012 · Harm · Low evidence

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HarmLow evidencePaper 3131

Male Fischer-344 rats exposed for 30 days (2 h/day) to 900 MHz (SAR = 5.953 × 10^-4 W/kg) or 1800 MHz (SAR = 5.835 × 10^-4 W/kg) microwave radiation showed significant impairment in cognitive function and increased oxidative stress in brain tissue compared wi…

Study snapshot

PublicationIndian journal of experimental biology · 2012
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

Public concerns over possible adverse effects of microwave radiation emitted by mobile phones on health are increasing. To evaluate the intensity of oxidative stress, cognitive impairment and inflammation in brain of Fischer rats exposed to microwave radiation, male Fischer-344 rats were exposed to 900 MHz microwave radiation (SAR = 5.953 x 10(-4) W/kg) and 1800 MHz microwave radiation (SAR = 5.835 x 10(-4) W/kg) for 30 days (2 h/day). Significant impairment in cognitive function and induction of oxidative stress in brain tissues of microwave exposed rats were observed in comparison with sham exposed groups. Further, significant increase in level of cytokines (IL-6 and TNF-alpha) was also observed following microwave exposure. Results of the present study indicated that increased oxidative stress due to microwave exposure may contribute to cognitive impairment and inflammation in brain.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationMale Fischer-344 rats
Sample sizeNot supplied
ExposureRF · 30 days (2 h/day)
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Male Fischer-344 rats exposed for 30 days (2 h/day) to 900 MHz (SAR = 5.953 × 10^-4 W/kg) or 1800 MHz (SAR = 5.835 × 10^-4 W/kg) microwave radiation showed significant impairment in cognitive function and increased oxidative stress in brain tissue compared with sham-exposed groups. IL-6 and TNF-alpha levels were also significantly increased following exposure.

Outcomes measured

  • Cognitive function
  • Oxidative stress in brain tissue
  • Inflammatory cytokines (IL-6, TNF-alpha)

Limitations

  • Sample size not reported in abstract
  • Details of exposure setup and dosimetry beyond SAR values not described in abstract
  • Methods for cognitive testing and oxidative stress/inflammation assays not specified in abstract
  • Only male rats studied; generalizability to other sexes/species not addressed in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "30 days (2 h/day)"
  },
  "population": "Male Fischer-344 rats",
  "sample_size": null,
  "outcomes": [
    "Cognitive function",
    "Oxidative stress in brain tissue",
    "Inflammatory cytokines (IL-6, TNF-alpha)"
  ],
  "main_findings": "Male Fischer-344 rats exposed for 30 days (2 h/day) to 900 MHz (SAR = 5.953 × 10^-4 W/kg) or 1800 MHz (SAR = 5.835 × 10^-4 W/kg) microwave radiation showed significant impairment in cognitive function and increased oxidative stress in brain tissue compared with sham-exposed groups. IL-6 and TNF-alpha levels were also significantly increased following exposure.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in abstract",
    "Details of exposure setup and dosimetry beyond SAR values not described in abstract",
    "Methods for cognitive testing and oxidative stress/inflammation assays not specified in abstract",
    "Only male rats studied; generalizability to other sexes/species not addressed in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "radiofrequency",
    "900 MHz",
    "1800 MHz",
    "SAR",
    "oxidative stress",
    "cognitive impairment",
    "inflammation",
    "IL-6",
    "TNF-alpha",
    "Fischer-344 rats"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 23986973

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