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Environmental Factors That Influence Stem Cell Migration: An "Electric Field"

2017 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 2232

This review discusses how endogenous electric fields (electric potential gradients) can direct cell movement (galvanotaxis) and summarizes literature on mechanisms by which stem cells sense and transduce electric fields into directed migration, with comments …

Study snapshot

Publicationmanual · 2017
Study typereview
Reported directionUnclear
Evidence ratingInsufficient

Abstract

Environmental Factors That Influence Stem Cell Migration: An "Electric Field" Iwasa SN, Babona-Pilipos R, Morshead CM. Environmental Factors That Influence Stem Cell Migration: An "Electric Field". Stem Cells Int. 2017;2017:4276927. doi: 10.1155/2017/4276927. Abstract Environmental Stimulus of Electric Fields on Stem Cell Migration. The movement of cells in response to electric potential gradients is called galvanotaxis. In vivo galvanotaxis, powered by endogenous electric fields (EFs), plays a critical role during development and wound healing. This review aims to provide a perspective on how stem cells transduce EFs into directed migration and an understanding of the current literature relating to the mechanisms by which cells sense and transduce EFs. We will comment on potential EF-based regenerative medicine therapeutics. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typereview
Effect directionunclear
PopulationNot supplied
Sample sizeNot supplied
ExposureNot supplied
Evidence strengthInsufficientConfidence: 66% · Peer reviewed: unknown

Main findings

This review discusses how endogenous electric fields (electric potential gradients) can direct cell movement (galvanotaxis) and summarizes literature on mechanisms by which stem cells sense and transduce electric fields into directed migration, with comments on potential EF-based regenerative medicine therapeutics.

Outcomes measured

  • stem cell migration
  • galvanotaxis
  • mechanisms of electric-field sensing/transduction
  • regenerative medicine therapeutics (potential)
View raw extracted JSON
{
  "study_type": "review",
  "exposure": {
    "band": null,
    "source": "endogenous electric fields",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "stem cell migration",
    "galvanotaxis",
    "mechanisms of electric-field sensing/transduction",
    "regenerative medicine therapeutics (potential)"
  ],
  "main_findings": "This review discusses how endogenous electric fields (electric potential gradients) can direct cell movement (galvanotaxis) and summarizes literature on mechanisms by which stem cells sense and transduce electric fields into directed migration, with comments on potential EF-based regenerative medicine therapeutics.",
  "effect_direction": "unclear",
  "limitations": [],
  "evidence_strength": "insufficient",
  "confidence": 0.66,
  "peer_reviewed_likely": "unknown",
  "keywords": [
    "electric fields",
    "endogenous electric fields",
    "electric potential gradients",
    "galvanotaxis",
    "stem cells",
    "cell migration",
    "development",
    "wound healing",
    "regenerative medicine"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1155/2017/4276927
PubMed: Not supplied

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