A review on point mutations via proton transfer in DNA base pairs in the absence and presence of

International Journal of Biological Macromolecules · 2024 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 107

Study snapshot

PublicationInternational Journal of Biological Macromolecules · 2024

Study typereview

Reported directionUnclear

Evidence ratingInsufficient

Abstract

A review on point mutations via proton transfer in DNA base pairs in the absence and presence of electric fields Pushkaran AC, Arabi AA. A review on point mutations via proton transfer in DNA base pairs in the absence and presence of electric fields. Int J Biol Macromol. 2024 Jul 26:134051. doi: 10.1016/j.ijbiomac.2024.134051. Abstract This is a comprehensive review that focuses on spontaneous mutations that may occur during DNA replication, the fundamental process responsible for transferring genetic information. In 1963, Löwdin postulated that these mutations are primarily a result of proton transfer reactions within the hydrogen- bonded DNA base pairs. The single and double proton transfer reactions within the base pairs result in zwitterions and rare tautomers, respectively. For persistent mutations, these products must be generated at high rates and should be thermodynamically stable. This review covers the proton transfer reactions studied experimentally and computationally. The review also examines the influence of externally applied electric fields on the thermodynamics and kinetics of proton transfer reactions within DNA base pairs, and their biological implications. Open access paper: sciencedirect.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typereview

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: unknown

Main findings

The review summarizes experimental and computational studies of single and double proton transfer in DNA base pairs (leading to zwitterions and rare tautomers) and discusses how externally applied electric fields may influence the thermodynamics and kinetics of these proton transfer reactions, with potential biological implications for spontaneous mutations during DNA replication.

Outcomes measured

Proton transfer reactions in hydrogen-bonded DNA base pairs
Formation of zwitterions and rare tautomers via single/double proton transfer
Thermodynamics and kinetics of proton transfer reactions
Spontaneous/point mutations during DNA replication (mechanistic link via proton transfer)
Influence of externally applied electric fields on proton transfer reactions and biological implications

Limitations

No specific electric-field exposure parameters (e.g., field strength, frequency, duration) are provided in the abstract.
As a review, it synthesizes prior work rather than presenting new primary experimental results (details not provided in the abstract).

View raw extracted JSON

{
  "study_type": "review",
  "exposure": {
    "band": null,
    "source": "externally applied electric fields",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Proton transfer reactions in hydrogen-bonded DNA base pairs",
    "Formation of zwitterions and rare tautomers via single/double proton transfer",
    "Thermodynamics and kinetics of proton transfer reactions",
    "Spontaneous/point mutations during DNA replication (mechanistic link via proton transfer)",
    "Influence of externally applied electric fields on proton transfer reactions and biological implications"
  ],
  "main_findings": "The review summarizes experimental and computational studies of single and double proton transfer in DNA base pairs (leading to zwitterions and rare tautomers) and discusses how externally applied electric fields may influence the thermodynamics and kinetics of these proton transfer reactions, with potential biological implications for spontaneous mutations during DNA replication.",
  "effect_direction": "unclear",
  "limitations": [
    "No specific electric-field exposure parameters (e.g., field strength, frequency, duration) are provided in the abstract.",
    "As a review, it synthesizes prior work rather than presenting new primary experimental results (details not provided in the abstract)."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "unknown",
  "keywords": [
    "DNA replication",
    "point mutations",
    "spontaneous mutations",
    "proton transfer",
    "hydrogen-bonded base pairs",
    "tautomers",
    "zwitterions",
    "electric fields",
    "thermodynamics",
    "kinetics"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.ijbiomac.2024.134051
PubMed: Not supplied

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