RAPD Profiling, DNA Fragmentation, and Histomorphometric Examination in Brains of Wistar Rats Exposed to

2017 · Harm · Low evidence

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HarmLow evidencePaper 2201

Rats exposed to indoor 2.5 GHz Wi‑Fi device radiation for 30, 45, or 60 days showed histopathological/histomorphometric brain alterations (including vascular/perivascular congestion and tissue damage) and evidence of DNA damage based on agarose gel electropho…

Study snapshot

Publicationmanual · 2017

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

RAPD Profiling, DNA Fragmentation, and Histomorphometric Examination in Brains of Wistar Rats Exposed to Indoor 2.5 Ghz Wi-Fi Devices Radiation Ibitayo AO, Afolabi OB, Akinyemi AJ, Ojiezeh TI, Adekoya KO, Ojewunmi OO. RAPD Profiling, DNA Fragmentation, and Histomorphometric Examination in Brains of Wistar Rats Exposed to Indoor 2.5 Ghz Wi-Fi Devices Radiation. Biomed Res Int. 2017;2017:8653286. Abstract The advent of Wi-Fi connected high technology devices in executing day-to-day activities is fast evolving especially in developing countries of the world and hence the need to assess its safety among others. The present study was conducted to investigate the injurious effect of radiofrequency emissions from installed Wi-Fi devices in brains of young male rats. Animals were divided into four equal groups; group 1 served as control while groups 2, 3, and 4 were exposed to 2.5 Ghz at intervals of 30, 45, and 60 consecutive days with free access to food and water ad libitum. Alterations in harvested brain tissues were confirmed by histopathological analyses which showed vascular congestion and DNA damage in the brain was assayed using agarose gel electrophoresis. Histomorphometry analyses of their brain tissues showed perivascular congestion and tissue damage as well. Conclusion In this study, the effect of Wi-Fi radiation exposure as a threat to brain health was studied using genomic analysis and histopathological study which showed the high risk of its genotoxicity especially in prolonged exposure spectrum through the findings from this study. The genomic analysis confirmed DNA damage due to Wi-Fi radiation toxicity and DNA damage effect which was seen through the RAPD profiles of animals from the exposed groups. The histopathological analyses also confirmed significant deleterious alterations in the brain tissues of Wi-Fi-exposed animals. Hence, the need to exhibit caution in handling smart devices that are used from day to day is fast becoming a threat to human health and wellness. Open Access Paper: ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationYoung male Wistar rats

Sample sizeNot supplied

ExposureRF · 2500 MHz · 30, 45, or 60 consecutive days

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

RAPD profiling (genomic alterations)
DNA fragmentation/DNA damage (agarose gel electrophoresis)
Histopathology/histomorphometry of brain tissue (e.g., vascular/perivascular congestion, tissue damage)

Limitations

Sample size not reported in the abstract
Exposure intensity/dosimetry (e.g., SAR, power density, distance) not reported in the abstract
Randomization/blinding not described in the abstract
Only young male rats studied; generalizability to other sexes/ages/species not addressed in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "wi-fi",
    "frequency_mhz": 2500,
    "sar_wkg": null,
    "duration": "30, 45, or 60 consecutive days"
  },
  "population": "Young male Wistar rats",
  "sample_size": null,
  "outcomes": [
    "RAPD profiling (genomic alterations)",
    "DNA fragmentation/DNA damage (agarose gel electrophoresis)",
    "Histopathology/histomorphometry of brain tissue (e.g., vascular/perivascular congestion, tissue damage)"
  ],
  "main_findings": "Rats exposed to indoor 2.5 GHz Wi‑Fi device radiation for 30, 45, or 60 days showed histopathological/histomorphometric brain alterations (including vascular/perivascular congestion and tissue damage) and evidence of DNA damage based on agarose gel electrophoresis and RAPD profiles, compared with controls.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in the abstract",
    "Exposure intensity/dosimetry (e.g., SAR, power density, distance) not reported in the abstract",
    "Randomization/blinding not described in the abstract",
    "Only young male rats studied; generalizability to other sexes/ages/species not addressed in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "Wi-Fi",
    "2.5 GHz",
    "radiofrequency",
    "Wistar rats",
    "brain",
    "genotoxicity",
    "DNA damage",
    "RAPD",
    "histopathology",
    "histomorphometry"
  ],
  "suggested_hubs": [
    {
      "slug": "school-wi-fi",
      "weight": 0.6,
      "reason": "Study evaluates biological effects from indoor Wi‑Fi device radiation (2.5 GHz)."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: Not supplied

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