RF Safe

Detection of Low Level Microwave Radiation Induced Deoxyribonucleic Acid Damage Vis-à-vis Genotoxicity in Brain of Fischer Rats.

Toxicology international · 2013 · Harm · Low evidence

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HarmLow evidencePaper 6542

Male Fischer rats exposed for 30 days to microwave radiation at 900, 1800, or 2450 MHz (SARs ~5.835×10^-4 to 6.672×10^-4 W/kg) showed DNA damaging effects in brain tissue assessed by alkaline comet assay, compared with sham-exposed animals.

Study snapshot

PublicationToxicology international · 2013
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

BACKGROUND: Non-ionizing radiofrequency radiation has been increasingly used in industry, commerce, medicine and especially in mobile phone technology and has become a matter of serious concern in present time. OBJECTIVE: The present study was designed to investigate the possible deoxyribonucleic acid (DNA) damaging effects of low-level microwave radiation in brain of Fischer rats. MATERIALS AND METHODS: Experiments were performed on male Fischer rats exposed to microwave radiation for 30 days at three different frequencies: 900, 1800 and 2450 MHz. Animals were divided into 4 groups: Group I (Sham exposed): Animals not exposed to microwave radiation but kept under same conditions as that of other groups, Group II: Animals exposed to microwave radiation at frequency 900 MHz at specific absorption rate (SAR) 5.953 × 10(-4) W/kg, Group III: Animals exposed to 1800 MHz at SAR 5.835 × 10(-4) W/kg and Group IV: Animals exposed to 2450 MHz at SAR 6.672 × 10(-4) W/kg. At the end of the exposure period animals were sacrificed immediately and DNA damage in brain tissue was assessed using alkaline comet assay. RESULTS: In the present study, we demonstrated DNA damaging effects of low level microwave radiation in brain. CONCLUSION: We concluded that low SAR microwave radiation exposure at these frequencies may induce DNA strand breaks in brain tissue.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationMale Fischer rats
Sample sizeNot supplied
ExposureRF · 30 days
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Male Fischer rats exposed for 30 days to microwave radiation at 900, 1800, or 2450 MHz (SARs ~5.835×10^-4 to 6.672×10^-4 W/kg) showed DNA damaging effects in brain tissue assessed by alkaline comet assay, compared with sham-exposed animals.

Outcomes measured

  • DNA damage in brain tissue (alkaline comet assay)
  • DNA strand breaks

Limitations

  • Sample size not reported in abstract.
  • Exposure source/setup and daily exposure schedule not described in abstract.
  • Only one endpoint (comet assay in brain) reported in abstract.
  • Quantitative results/statistics not provided in abstract.
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "30 days"
  },
  "population": "Male Fischer rats",
  "sample_size": null,
  "outcomes": [
    "DNA damage in brain tissue (alkaline comet assay)",
    "DNA strand breaks"
  ],
  "main_findings": "Male Fischer rats exposed for 30 days to microwave radiation at 900, 1800, or 2450 MHz (SARs ~5.835×10^-4 to 6.672×10^-4 W/kg) showed DNA damaging effects in brain tissue assessed by alkaline comet assay, compared with sham-exposed animals.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in abstract.",
    "Exposure source/setup and daily exposure schedule not described in abstract.",
    "Only one endpoint (comet assay in brain) reported in abstract.",
    "Quantitative results/statistics not provided in abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "radiofrequency radiation",
    "microwave radiation",
    "Fischer rats",
    "brain",
    "DNA damage",
    "genotoxicity",
    "comet assay",
    "900 MHz",
    "1800 MHz",
    "2450 MHz",
    "SAR"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.4103/0971-6580.111549
PubMed: 23833433

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