Effect of weak static & ELF alternating magnetic fields on memory & brain amyloid-β in two animal models of

2018 · Mixed · Low evidence

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MixedLow evidencePaper 2109

Subchronic exposure to a weak combined magnetic field (static 42 µT plus alternating 0.08 µT composed of 4.38 and 4.88 Hz) decreased Aβ levels in OBE mouse brain and reduced the number of Aβ plaques in cortex and hippocampus of transgenic mice. Memory improve…

Study snapshot

Publicationmanual · 2018

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Effect of weak static & ELF alternating magnetic fields on memory & brain amyloid-β in two animal models of Alzheimer's disease Bobkova NV, Novikov VV. Medvinskaya NI, Aleksandrova IY, Nesterova IV, Fesenko EE. Effect of weak combined static and extremely low-frequency alternating magnetic fields on spatial memory and brain amyloid-β in two animal models of Alzheimer's disease. Electromagnetic Biol Med. May 2018. Abstract Subchronic effect of a weak combined magnetic field (MF), produced by superimposing a constant component, 42 µT and an alternating MF of 0.08 µT, which was the sum of two frequencies of 4.38 and 4.88 Hz, was studied in olfactory bulbectomized (OBE) and transgenic Tg (APPswe, PSEN1) mice, which were used as animal models of sporadic and heritable Alzheimer's disease (AD) accordingly. Spatial memory was tested in a Morris water maze on the following day after completion of training trials with the hidden platform removed. The amyloid-β (Aβ) level was determined in extracts of the cortex and hippocampus of mice using a specific DOT analysis while the number and dimensions of amyloid plaques were detected after their staining with thioflavin S in transgenic animals. Exposure to the MFs (4 h/day for 10 days) induced the decrease of Aβ level in brain of OBE mice and reduced the number of Aβ plaques in the cortex and hippocampus of Tg animals. However, memory improvement was revealed in Tg mice only, but not in the OBE animals. Here, we suggest that in order to prevent the Aβ accumulation, MFs could be used at early stage of neuronal degeneration in case of AD and other diseases with amyloid protein deposition in other tissues. tandfonline.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationOlfactory bulbectomized (OBE) mice and transgenic Tg (APPswe, PSEN1) mice (animal models of sporadic and heritable Alzheimer's disease)

Sample sizeNot supplied

ExposureELF · 4 h/day for 10 days

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Spatial memory (Morris water maze)
Brain amyloid-β (Aβ) level in cortex and hippocampus (DOT analysis)
Amyloid plaque number and dimensions (thioflavin S staining; transgenic animals)

Limitations

Sample size not reported in provided abstract/metadata
Details on randomization/blinding and sham/control conditions not reported in provided abstract/metadata
Only short-term/subchronic exposure assessed; follow-up duration not reported

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "4 h/day for 10 days"
  },
  "population": "Olfactory bulbectomized (OBE) mice and transgenic Tg (APPswe, PSEN1) mice (animal models of sporadic and heritable Alzheimer's disease)",
  "sample_size": null,
  "outcomes": [
    "Spatial memory (Morris water maze)",
    "Brain amyloid-β (Aβ) level in cortex and hippocampus (DOT analysis)",
    "Amyloid plaque number and dimensions (thioflavin S staining; transgenic animals)"
  ],
  "main_findings": "Subchronic exposure to a weak combined magnetic field (static 42 µT plus alternating 0.08 µT composed of 4.38 and 4.88 Hz) decreased Aβ levels in OBE mouse brain and reduced the number of Aβ plaques in cortex and hippocampus of transgenic mice. Memory improvement was observed in transgenic mice but not in OBE mice.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Details on randomization/blinding and sham/control conditions not reported in provided abstract/metadata",
    "Only short-term/subchronic exposure assessed; follow-up duration not reported"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "extremely low frequency",
    "ELF magnetic field",
    "combined magnetic field",
    "42 µT",
    "0.08 µT",
    "4.38 Hz",
    "4.88 Hz",
    "Alzheimer's disease model",
    "olfactory bulbectomy",
    "transgenic mice",
    "APPswe",
    "PSEN1",
    "amyloid-β",
    "amyloid plaques",
    "Morris water maze"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/15368378.2018.1471700
PubMed: Not supplied

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