6-mT 0-120-Hz magnetic fields differentially affect cellular ATP levels

2018 · Mixed · Low evidence

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MixedLow evidencePaper 2060

Study snapshot

Publicationmanual · 2018

Study typein_vitro

Reported directionMixed

Evidence ratingLow

Abstract

6-mT 0-120-Hz magnetic fields differentially affect cellular ATP levels Wang D, Zhang L, Shao G, Yang S, Tao S, Fang K, Zhang X. 6-mT 0-120-Hz magnetic fields differentially affect cellular ATP levels. Environ Sci Pollut Res Int. 2018 Aug 3. doi: 10.1007/s11356-018-2868-3. Abstract Adenosine triphosphate (ATP), an indispensable molecule that provides energy for essentially all cellular processes, has been shown to be affected by some magnetic fields (MFs). Although people are frequently exposed to various static and power frequency MFs in their daily lives, the exact effects of these MFs of different frequencies have not been systematically investigated. Here, we tested 6-mT MFs with 0, 50, and 120 Hz for their effects on cellular ATP levels in 11 different cell lines. We found that the 6-mT static magnetic field (SMF) either does not affect or increase cellular ATP levels, while 6-mT 50-Hz MF either does not affect or decrease cellular ATP levels. In contrast, 6-mT 120-Hz MF has variable effects. We examined the mitochondrial membrane potential (MMP) as well as reactive oxygen species (ROS) in four different cell lines, but did not find their direct correlation with ATP levels. Although none of the ATP level changes induced by these three different frequencies of 6-mT MFs are dramatic, these results may be used to explain some differential cellular responses of various cell lines to different frequency MFs. ncbi.nlm.nih.gov Excerpt In conclusion, although the ATP level changes induced by 6-mT MFs are not dramatic, the exact effects are cell type-, MF frequency-, and time-dependent. These may help to explain some observed cellular phenomenon of low-frequency MFs. Given the prevalence of power frequency and SMF exposure for human bodies, such as the MFs generated by electric power lines, home appliance, and household items, people should be aware of their potential effects on cellular ATP, which is the foundation of many cellular processes.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionmixed

PopulationNot supplied

Sample size11

ExposureELF

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In 11 cell lines exposed to 6 mT magnetic fields at 0, 50, or 120 Hz, 6 mT static fields either did not affect or increased ATP levels, 6 mT 50-Hz fields either did not affect or decreased ATP levels, and 6 mT 120-Hz fields showed variable effects. In four cell lines, MMP and ROS were assessed but no direct correlation with ATP levels was found; ATP changes were described as not dramatic.

Outcomes measured

cellular ATP levels
mitochondrial membrane potential (MMP)
reactive oxygen species (ROS)

Limitations

Exposure duration/time course not specified in the provided abstract
Magnitude of ATP changes described as not dramatic; quantitative effect sizes not provided in the provided abstract
Mechanistic measures (MMP, ROS) assessed in only four of the 11 cell lines

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": 11,
  "outcomes": [
    "cellular ATP levels",
    "mitochondrial membrane potential (MMP)",
    "reactive oxygen species (ROS)"
  ],
  "main_findings": "In 11 cell lines exposed to 6 mT magnetic fields at 0, 50, or 120 Hz, 6 mT static fields either did not affect or increased ATP levels, 6 mT 50-Hz fields either did not affect or decreased ATP levels, and 6 mT 120-Hz fields showed variable effects. In four cell lines, MMP and ROS were assessed but no direct correlation with ATP levels was found; ATP changes were described as not dramatic.",
  "effect_direction": "mixed",
  "limitations": [
    "Exposure duration/time course not specified in the provided abstract",
    "Magnitude of ATP changes described as not dramatic; quantitative effect sizes not provided in the provided abstract",
    "Mechanistic measures (MMP, ROS) assessed in only four of the 11 cell lines"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "magnetic field",
    "static magnetic field",
    "ELF",
    "50 Hz",
    "120 Hz",
    "6 mT",
    "ATP",
    "cell lines",
    "mitochondrial membrane potential",
    "reactive oxygen species"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.2,
      "reason": "Discusses power-frequency and static magnetic fields relevant to everyday/utility sources (e.g., power lines, appliances), though study is in vitro."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/s11356-018-2868-3
PubMed: Not supplied

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