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Effects of power-frequency MF on cardiomyocytes differentiated from human induced pluripotent stem cells

2017 · No effect · Low evidence

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No effectLow evidencePaper 1343

Short-term exposure of a hiPS-CM monolayer to a 50 Hz magnetic field at 400 mT showed no significant difference in field potential duration pre- vs post-exposure, suggesting no effect on electrical activity under these conditions.

Study snapshot

Publicationmanual · 2017
Study typein_vitro
Reported directionNo effect
Evidence ratingLow

Abstract

Effects of power-frequency MF on cardiomyocytes differentiated from human induced pluripotent stem cells Takahashi M1, Saito A, Jimbo Y, Nakasono S. Evaluation of the effects of power-frequency magnetic fields on the electrical activity of cardiomyocytes differentiated from human induced pluripotent stem cells. J Toxicol Sci. 2017;42(2):223-231. doi: 10.2131/jts.42.223. Abstract Although cardiac activity is known to differ between species in many respects, most evaluations of the cardiac effects of low-frequency electric and magnetic fields, which have a stimulant effect on electrically activated cells, have been performed in non-human experimental animals and cells, and the effects in humans have been assessed using theoretical models. In recent years, it has been verified that human cardiomyocytes differentiated from human induced pluripotent stem cells (hiPS-CM) are useful for evaluating human responses to various cardioactive compounds. In this study, we applied hiPSCMs for the first time to evaluate the human cardiac effects of power-frequency magnetic fields (MFs). After preparation of hiPS-CMs, we subjected a hiPS- CM monolayer formed on a multi-electrode array to short-term exposure to a 50 Hz MF at 400 mT with recording of the extracellular field potentials. The field potential duration of the hiPS-CMs did not differ significantly pre- and post-exposure, indicating that under these conditions, exposure to a 50 Hz MF at 400 mT does not affect the electrical activity of hiPSCMs. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionno_effect
PopulationCardiomyocytes differentiated from human induced pluripotent stem cells (hiPS-CMs)
Sample sizeNot supplied
ExposureELF · 0.05 MHz · short-term
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Short-term exposure of a hiPS-CM monolayer to a 50 Hz magnetic field at 400 mT showed no significant difference in field potential duration pre- vs post-exposure, suggesting no effect on electrical activity under these conditions.

Outcomes measured

  • Extracellular field potentials
  • Field potential duration (FPD)

Limitations

  • Exposure duration not specified beyond 'short-term'
  • Sample size not reported in the provided abstract
  • Only one exposure condition reported (50 Hz, 400 mT)
  • In vitro model; may not represent whole-organism cardiac responses
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "short-term"
  },
  "population": "Cardiomyocytes differentiated from human induced pluripotent stem cells (hiPS-CMs)",
  "sample_size": null,
  "outcomes": [
    "Extracellular field potentials",
    "Field potential duration (FPD)"
  ],
  "main_findings": "Short-term exposure of a hiPS-CM monolayer to a 50 Hz magnetic field at 400 mT showed no significant difference in field potential duration pre- vs post-exposure, suggesting no effect on electrical activity under these conditions.",
  "effect_direction": "no_effect",
  "limitations": [
    "Exposure duration not specified beyond 'short-term'",
    "Sample size not reported in the provided abstract",
    "Only one exposure condition reported (50 Hz, 400 mT)",
    "In vitro model; may not represent whole-organism cardiac responses"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "power-frequency",
    "magnetic field",
    "50 Hz",
    "400 mT",
    "ELF",
    "cardiomyocytes",
    "hiPS-CM",
    "human induced pluripotent stem cells",
    "multi-electrode array",
    "field potential duration"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.35,
      "reason": "Study evaluates effects of a high-intensity power-frequency (50 Hz) magnetic field, relevant to occupational ELF MF contexts."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.2131/jts.42.223
PubMed: Not supplied

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