RF Safe

Chronotoxicity of 1.8 GHz radio-frequency radiation on plasma stress hormones and immune factors in mice

2019 · Harm · Low evidence

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HarmLow evidencePaper 1788

After 60 days of 1.8 GHz RF exposure (226 μW/cm^2, 2 h/day), daily average plasma levels of ACTH, CORT, GM-CSF, and TNF-α were significantly decreased compared with sham (P<0.05). Circadian rhythms of CORT, GM-CSF, and TNF-α were reported to disappear, and AC…

Study snapshot

Publicationmanual · 2019
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

Chronotoxicity of 1.8 GHz radio-frequency radiation on plasma stress hormones and immune factors in mice Qin F, Shen T, Li J, Xu B, Chen Y, Zheng ZA, Zou D. [Chronotoxicity of 1.8 GHz radio-frequency radiation on plasma stress hormones and immune factors in mice]. [Article in Chinese]. Wei Sheng Yan Jiu. 2019 May;48(3):482-487. Abstract OBJECTIVE: To study the chronotoxicity of radio-frequency radiation(RF) on the plasma stress hormones and immune factors in mice. METHODS: A total of 72 healthy C57 BL mice with circadian rhythm were divided into twelve groups: 6 Sham group and 6 RF groups. RF groups were exposed to 1.8 GHz RF at 226 μW/cm~2 for 60 days with 2 h/day respectively at corresponding zeitgeber time(ZT 0:00, ZT 4:00, ZT 8:00, ZT 12:00, ZT 16:00, ZT 20:00). The Sham group mice were exposed to the same condition without electromagnetic signal. At the end of last RF exposure, blood samples were collected from each animal. The concentrations of plasma stress hormones(ACTH, CORT) and immune factors(GM-CSF, TNF-α) were determined by enzyme linked immunosorbent assay(ELISA) method. RESULTS: The daily average levels of ACTH, CORT, GM-CSF and TNF-α were 84.12, 60.14, 1112.02 and 594.49 ng/L, which were decreased to 62.07, 41.21, 84.18 and 305.08 ng/L after 60 days of RF exposure. Compared to sham-exposed animals, the daily average levels of ACTH, CORT, GM-CSF and TNF-α were all significantly decreased(P<0.05). Circadian rhythms in the secreting of CORT, GM-CSF, TNF-α were disappeared(P>0.05), circadian rhythms of ACTH was shifted in RF-exposed mice, with the amplitude reduced from 12.45 to 4.88 and peak time postponed from 1:39 to 5:29. CONCLUSION: 1.8 GHz RF may weaken the function of stress and immune, and disturb their circadian rhythmicities. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationHealthy C57 BL mice with circadian rhythm
Sample size72
ExposureRF · 1800 MHz · 60 days; 2 h/day; exposures at ZT 0, 4, 8, 12, 16, 20
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

After 60 days of 1.8 GHz RF exposure (226 μW/cm^2, 2 h/day), daily average plasma levels of ACTH, CORT, GM-CSF, and TNF-α were significantly decreased compared with sham (P<0.05). Circadian rhythms of CORT, GM-CSF, and TNF-α were reported to disappear, and ACTH rhythm was shifted with reduced amplitude and delayed peak time in RF-exposed mice.

Outcomes measured

  • Plasma ACTH
  • Plasma corticosterone (CORT)
  • Plasma GM-CSF
  • Plasma TNF-α
  • Circadian rhythm parameters (presence/absence, amplitude, peak time shift)

Limitations

  • No SAR reported (only power density given)
  • Only one species/strain (C57 BL mice)
  • Endpoints limited to selected plasma hormones/cytokines measured at end of exposure period
  • Exposure source/setup details not described in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 1800,
    "sar_wkg": null,
    "duration": "60 days; 2 h/day; exposures at ZT 0, 4, 8, 12, 16, 20"
  },
  "population": "Healthy C57 BL mice with circadian rhythm",
  "sample_size": 72,
  "outcomes": [
    "Plasma ACTH",
    "Plasma corticosterone (CORT)",
    "Plasma GM-CSF",
    "Plasma TNF-α",
    "Circadian rhythm parameters (presence/absence, amplitude, peak time shift)"
  ],
  "main_findings": "After 60 days of 1.8 GHz RF exposure (226 μW/cm^2, 2 h/day), daily average plasma levels of ACTH, CORT, GM-CSF, and TNF-α were significantly decreased compared with sham (P<0.05). Circadian rhythms of CORT, GM-CSF, and TNF-α were reported to disappear, and ACTH rhythm was shifted with reduced amplitude and delayed peak time in RF-exposed mice.",
  "effect_direction": "harm",
  "limitations": [
    "No SAR reported (only power density given)",
    "Only one species/strain (C57 BL mice)",
    "Endpoints limited to selected plasma hormones/cytokines measured at end of exposure period",
    "Exposure source/setup details not described in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "1.8 GHz",
    "radio-frequency radiation",
    "RF exposure",
    "chronotoxicity",
    "circadian rhythm",
    "ACTH",
    "corticosterone",
    "GM-CSF",
    "TNF-α",
    "mouse",
    "ELISA"
  ],
  "suggested_hubs": [
    {
      "slug": "who-icnirp",
      "weight": 0.2,
      "reason": "Animal study on RF biological effects potentially relevant to RF health risk assessments."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

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PubMed: Not supplied

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