Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone

Med Science · 2024 · Mixed · Low evidence

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MixedLow evidencePaper 131

In rat brain tissue, p38MAPK gene expression was upregulated in the 1.8 GHz RF-EMF exposed group compared with controls (p=0.018). Hsp27 gene expression was not altered (p=0.897).

Study snapshot

PublicationMed Science · 2024

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone radiofrequency electromagnetic field Arslan B, Aras N, Yaman S, Comelekoglu U. Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone radiofrequency electromagnetic field. Med Science. 2024;13(1):78- 82. Abstract Heat Shock Proteins (HSPs) may induce various cellular processes, including replication, apoptosis, cell- cycle progression. Mitogen-activated protein kinase (MAPK) cascades are the primary mechanism that mediates the cellular stress response to extracellular stimuli and regulates transcriptional activity. It has been shown that mobile phone exposure can stimulate the Hsp27/p38MAPK stress pathway. In this study, twenty-seven mature female Wistar albino rats were exposed to 1.8 GHz radiofrequency electromagnetic field (RF-EMF) 2h/day for 8 weeks (SAR: 0.06 W/kg). Hsp27 and p38MAPK gene expressions were investigated in rat brains. Rats were divided into groups sham-exposed, cage control, and 1.8 GHz RF-EMF exposed. Hsp27 and p38MAPK gene expression levels were investigated from the brain. p38MAPK expression was found to be upregulated in RF-EMF exposed group (p=0.018) Hsp27 expressions were not altered (p=0.897). In conclusion, long-term exposure to 1.8 GHz cell phone radiation can activate the Hsp27/p38MAPK stress pathway. It may cause several cellular disorders and can affect brain function. Open access paper: medicinescience.org

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationMature female Wistar albino rats

Sample size27

ExposureRF · 1800 MHz · 0.06 W/kg · 2 h/day for 8 weeks

Evidence strengthLowConfidence: 78% · Peer reviewed: unknown

Main findings

In rat brain tissue, p38MAPK gene expression was upregulated in the 1.8 GHz RF-EMF exposed group compared with controls (p=0.018). Hsp27 gene expression was not altered (p=0.897).

Outcomes measured

Hsp27 gene expression (brain)
p38MAPK gene expression (brain)

Limitations

Only female rats were studied
Outcome measures limited to Hsp27 and p38MAPK gene expression in brain tissue
Exposure details beyond frequency, SAR, and schedule are not described in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": 1800,
    "sar_wkg": 0.06,
    "duration": "2 h/day for 8 weeks"
  },
  "population": "Mature female Wistar albino rats",
  "sample_size": 27,
  "outcomes": [
    "Hsp27 gene expression (brain)",
    "p38MAPK gene expression (brain)"
  ],
  "main_findings": "In rat brain tissue, p38MAPK gene expression was upregulated in the 1.8 GHz RF-EMF exposed group compared with controls (p=0.018). Hsp27 gene expression was not altered (p=0.897).",
  "effect_direction": "mixed",
  "limitations": [
    "Only female rats were studied",
    "Outcome measures limited to Hsp27 and p38MAPK gene expression in brain tissue",
    "Exposure details beyond frequency, SAR, and schedule are not described in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "unknown",
  "keywords": [
    "1.8 GHz",
    "RF-EMF",
    "cell phone",
    "rat",
    "brain",
    "Hsp27",
    "p38MAPK",
    "stress pathway",
    "gene expression",
    "SAR 0.06 W/kg"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones",
      "weight": 0.9,
      "reason": "Study examines 1.8 GHz cell phone RF-EMF exposure."
    },
    {
      "slug": "animal-studies",
      "weight": 0.85,
      "reason": "Experimental exposure study in rats."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: Not supplied

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