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Exposure to 50 Hz magnetic field at 100 µT exert no DNA damage in cardiomyocytes.

2019 · No effect · Low evidence

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No effectLow evidencePaper 1731

Human ventricular cardiomyocytes exposed to 50 Hz ELF-MF at 100 µT (1 hr continuous or 75 min intermittent) showed no DNA damage, no change in cell cycle distribution, and no increase in ROS. In rats exposed to 50 Hz MF at 100 µT for 7 days versus sham, no si…

Study snapshot

Publicationmanual · 2019
Study typeanimal
Reported directionNo effect
Evidence ratingLow

Abstract

Exposure to 50 Hz magnetic field at 100 µT exert no DNA damage in cardiomyocytes. Wang Y, Liu X, Zhang Y, Wan B, Zhang J, He W, Hu D, Yang Y, Lai J, He M, Chen C. Exposure to 50 Hz magnetic field at 100 µT exert no DNA damage in cardiomyocytes. Biol Open. 2019 Jul 30. pii: bio.041293. doi: 10.1242/bio.041293. Abstract The effects of exposure to magnetic fields (MFs) at city electric frequencies (50-60 Hz) on carcinogenicity are still in debate. Besides, whether exposure to MFs affects the heart is also a debated issue. This study aimed to determine whether exposure to extremely low frequency magnetic fields (ELF-MFs) induced DNA damage in cardiomyocytes both in vitro and in vivo. Human ventricular cardiomyocytes were exposed to 50 Hz ELF-MF at 100 µT for 1 hr continuously or 75 min intermittently. The effects of the treatments were evaluated by DNA damage, redox status changes, and relative signal molecular expression. Moreover, ten male Sprague-Dawley rats were exposed to a 50 Hz MF at 100 µT for 7 days, while another 10 rats were sham exposed. The protein levels of p53 and Hsp70 in heart tissue were analyzed by western blot. The results showed that exposure to ELF- MF did not induce DNA damage, cell cycle distribution change, or increased ROS level. No significant differences were detected in p53 and Hsp70 expression level between the ELF-MF and sham-exposure groups both in vitro and in vivo. All these data indicated that MFs at power-frequency may not cause DNA damage in cardiomyocyte. Open access paper: bio.biologists.org

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionno_effect
PopulationHuman ventricular cardiomyocytes (in vitro) and male Sprague-Dawley rats (in vivo)
Sample size20
ExposureELF · 0.05 MHz · In vitro: 1 hr continuous or 75 min intermittent; In vivo: 7 days
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Human ventricular cardiomyocytes exposed to 50 Hz ELF-MF at 100 µT (1 hr continuous or 75 min intermittent) showed no DNA damage, no change in cell cycle distribution, and no increase in ROS. In rats exposed to 50 Hz MF at 100 µT for 7 days versus sham, no significant differences were detected in p53 or Hsp70 expression in heart tissue.

Outcomes measured

  • DNA damage
  • cell cycle distribution
  • ROS level
  • redox status changes
  • p53 protein expression (heart tissue)
  • Hsp70 protein expression (heart tissue)

Limitations

  • Journal name not provided in metadata (though cited as Biol Open in abstract)
  • Sample size for in vitro experiments not stated
  • Only one field strength (100 µT) and one frequency (50 Hz) evaluated
  • In vivo outcomes limited to p53 and Hsp70 protein levels in heart tissue
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "power-frequency magnetic field",
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "In vitro: 1 hr continuous or 75 min intermittent; In vivo: 7 days"
  },
  "population": "Human ventricular cardiomyocytes (in vitro) and male Sprague-Dawley rats (in vivo)",
  "sample_size": 20,
  "outcomes": [
    "DNA damage",
    "cell cycle distribution",
    "ROS level",
    "redox status changes",
    "p53 protein expression (heart tissue)",
    "Hsp70 protein expression (heart tissue)"
  ],
  "main_findings": "Human ventricular cardiomyocytes exposed to 50 Hz ELF-MF at 100 µT (1 hr continuous or 75 min intermittent) showed no DNA damage, no change in cell cycle distribution, and no increase in ROS. In rats exposed to 50 Hz MF at 100 µT for 7 days versus sham, no significant differences were detected in p53 or Hsp70 expression in heart tissue.",
  "effect_direction": "no_effect",
  "limitations": [
    "Journal name not provided in metadata (though cited as Biol Open in abstract)",
    "Sample size for in vitro experiments not stated",
    "Only one field strength (100 µT) and one frequency (50 Hz) evaluated",
    "In vivo outcomes limited to p53 and Hsp70 protein levels in heart tissue"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency",
    "ELF-MF",
    "50 Hz",
    "100 µT",
    "magnetic field",
    "cardiomyocytes",
    "DNA damage",
    "ROS",
    "p53",
    "Hsp70",
    "Sprague-Dawley rats"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.35,
      "reason": "Power-frequency (50 Hz) magnetic field exposure is relevant to occupational ELF exposure contexts."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1242/bio.041293
PubMed: Not supplied

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