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Genotoxic effects of intermediate frequency magnetic fields on blood leukocytes in vitro

2019 · Mixed · Low evidence

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MixedLow evidencePaper 1689

Blood samples exposed to intermediate frequency magnetic fields at 123.90 kHz and 250.80 kHz showed a statistically significant increase in DNA damage only after 20 h exposure; other exposure durations were not reported as significant in the abstract.

Study snapshot

Publicationmanual · 2019
Study typein_vitro
Reported directionMixed
Evidence ratingLow

Abstract

Genotoxic effects of intermediate frequency magnetic fields on blood leukocytes in vitro Brech A, Kubinyi G, Németh Z, Bakos J, Fiocchi S, Thuróczy G. Genotoxic effects of intermediate frequency magnetic fields on blood leukocytes in vitro. Mutat Res. 2019 Sep;845:403060. doi: 10.1016/j.mrgentox.2019.05.016. Abstract The widespread presence of electromagnetic sources in daily life has initiated several studies on the effects of radiofrequency and power frequency fields. Only few investigations on the genotoxic effects of exposure to intermediate frequency magnetic fields (IF-MF) have been done so far. Therefore, the aim of this study was to evaluate possible genotoxic effects of exposure to 123.90 kHz and 250.80 kHz IF-MF on canine and human blood. Blood was exposed to IF-MF at 630 A/m (0.79 mT) and 80 A/m (0.10 m T) with exposure durations of 1-5 h (hourly), 20 and 24 h. Cylindrically divided Petri dish system was developed for in vitro exposures where different induced current could be achieved in the samples at the same magnetic flux density level. For the assessment of genotoxicity the alkaline comet assay was applied. We detected a statistically significant increase in DNA damage only following 20 h exposure to IF-MF. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionmixed
PopulationCanine and human blood leukocytes (in vitro)
Sample sizeNot supplied
Exposureintermediate frequency · 1–5 h (hourly), 20 h, 24 h
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Blood samples exposed to intermediate frequency magnetic fields at 123.90 kHz and 250.80 kHz showed a statistically significant increase in DNA damage only after 20 h exposure; other exposure durations were not reported as significant in the abstract.

Outcomes measured

  • DNA damage (alkaline comet assay)
  • Genotoxicity

Limitations

  • Sample size not reported in abstract
  • Only alkaline comet assay mentioned; no other genotoxicity endpoints described
  • In vitro blood exposure; relevance to in vivo health outcomes not addressed in abstract
  • Details on which frequency/intensity conditions drove the significant effect are not specified in the abstract
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "intermediate frequency",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "1–5 h (hourly), 20 h, 24 h"
  },
  "population": "Canine and human blood leukocytes (in vitro)",
  "sample_size": null,
  "outcomes": [
    "DNA damage (alkaline comet assay)",
    "Genotoxicity"
  ],
  "main_findings": "Blood samples exposed to intermediate frequency magnetic fields at 123.90 kHz and 250.80 kHz showed a statistically significant increase in DNA damage only after 20 h exposure; other exposure durations were not reported as significant in the abstract.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Only alkaline comet assay mentioned; no other genotoxicity endpoints described",
    "In vitro blood exposure; relevance to in vivo health outcomes not addressed in abstract",
    "Details on which frequency/intensity conditions drove the significant effect are not specified in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "intermediate frequency magnetic fields",
    "IF-MF",
    "123.90 kHz",
    "250.80 kHz",
    "blood leukocytes",
    "canine blood",
    "human blood",
    "in vitro",
    "alkaline comet assay",
    "DNA damage",
    "genotoxicity"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.mrgentox.2019.05.016
PubMed: Not supplied

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