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In vivo genotoxicity of high-intensity intermediate frequency magnetic fields in somatic cells and germ cells

Journal of radiation research · 2022 · No effect · Low evidence

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No effectLow evidencePaper 631

In hematopoietic cells, micronucleus and Pig-a assay results showed no significant increases in reticulocytes or mature erythrocytes in IF-MF-exposed mice versus sham. In germ cells, micronucleus and gpt assay outcomes indicated no genetic or chromosomal abno…

Study snapshot

PublicationJournal of radiation research · 2022
Study typeanimal
Reported directionNo effect
Evidence ratingLow

Abstract

In vivo genotoxicity of high-intensity intermediate frequency magnetic fields in somatic cells and germ cells Ohtani S, Ushiyama A, Wada K, Suzuki Y, Hattori K. In vivo genotoxicity of high-intensity intermediate frequency magnetic fields in somatic cells and germ cells. J Radiat Res. 2022 Dec 29:rrac081. doi: 10.1093/jrr/rrac081. Abstract Intermediate frequency magnetic fields (IF-MFs) at ~85 kHz are one of the components of wireless power transfer (WPT) systems. However, the available data needed for the assessment of the safety of organisms from IF-MF exposure are scarce. Thus, there is an imminent need to accumulate evidence-based assessment data. In particular, if humans are exposed to IF-MF due to an accident or trouble, they are at increased risk of being exposed to high-intensity IF-MF within a short period. The already existing exposure system was improved to a system that could intermittently expose animals at 3 s intervals. This system allows the exposure of a mouse to high-intensity IF-MF (frequency: 82.3 kHz; induced electric field: 87 V/m, which was 3.8 times the basic restriction level for occupational exposure in the ICNIRP guideline), while regulating the heat generated by the coil. In vivo genotoxicity after IF-MF exposure was assessed using micronucleus (MN) test, Pig-a assay, and gpt assay. The results of MN test and Pig-a assay in hematopoietic cells revealed that neither the reticulocytes nor the mature erythrocytes exhibited significant increases in the IF-MF-exposed group compared with that in the sham-exposed group. In germ cells, MN test and gpt assay outcomes showed that IF-MF exposure did not cause any genetic or chromosomal abnormality. Based on these data, there was no genotoxic effect of our set IF-MF exposure on somatic and germ cells. These findings can contribute to the widespread use of WPT systems as effective data of IF-MF safety assessment. pubmed.ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionno_effect
PopulationMouse
Sample sizeNot supplied
Exposureintermediate frequency · 0.0823 MHz · intermittent exposure at 3 s intervals
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In hematopoietic cells, micronucleus and Pig-a assay results showed no significant increases in reticulocytes or mature erythrocytes in IF-MF-exposed mice versus sham. In germ cells, micronucleus and gpt assay outcomes indicated no genetic or chromosomal abnormalities; overall, no genotoxic effect was observed under the described IF-MF exposure conditions.

Outcomes measured

  • Genotoxicity in hematopoietic cells (micronucleus test)
  • Mutagenicity in hematopoietic cells (Pig-a assay)
  • Genotoxicity/mutagenicity in germ cells (micronucleus test, gpt assay)

Limitations

  • Sample size not reported in abstract
  • Exposure duration/total exposure time not specified in abstract
  • Only genotoxicity endpoints assessed (MN, Pig-a, gpt); other health outcomes not addressed
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "intermediate frequency",
    "source": "wireless power transfer (WPT) systems",
    "frequency_mhz": 0.0823,
    "sar_wkg": null,
    "duration": "intermittent exposure at 3 s intervals"
  },
  "population": "Mouse",
  "sample_size": null,
  "outcomes": [
    "Genotoxicity in hematopoietic cells (micronucleus test)",
    "Mutagenicity in hematopoietic cells (Pig-a assay)",
    "Genotoxicity/mutagenicity in germ cells (micronucleus test, gpt assay)"
  ],
  "main_findings": "In hematopoietic cells, micronucleus and Pig-a assay results showed no significant increases in reticulocytes or mature erythrocytes in IF-MF-exposed mice versus sham. In germ cells, micronucleus and gpt assay outcomes indicated no genetic or chromosomal abnormalities; overall, no genotoxic effect was observed under the described IF-MF exposure conditions.",
  "effect_direction": "no_effect",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure duration/total exposure time not specified in abstract",
    "Only genotoxicity endpoints assessed (MN, Pig-a, gpt); other health outcomes not addressed"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "intermediate frequency magnetic fields",
    "IF-MF",
    "wireless power transfer",
    "WPT",
    "82.3 kHz",
    "induced electric field",
    "ICNIRP",
    "occupational exposure",
    "micronucleus test",
    "Pig-a assay",
    "gpt assay",
    "genotoxicity",
    "germ cells",
    "somatic cells",
    "mouse"
  ],
  "suggested_hubs": [
    {
      "slug": "who-icnirp",
      "weight": 0.6,
      "reason": "Exposure level is explicitly compared to the ICNIRP basic restriction level for occupational exposure."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1093/jrr/rrac081
PubMed: 36579461

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