An Extremely Low Frequency Magnetic Field and Global Cerebral Ischemia Affect Pituitary ACTH and TSH Cells in Gerbils

2019 · Mixed · Low evidence

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MixedLow evidencePaper 1652

Study snapshot

Publicationmanual · 2019

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

An Extremely Low Frequency Magnetic Field and Global Cerebral Ischemia Affect Pituitary ACTH and TSH Cells in Gerbils Rauš Balind SManojlović-Stojanoski M, Šošić-Jurjević B, Selaković V, Milošević V, Petković B. An Extremely Low Frequency Magnetic Field and Global Cerebral Ischemia Affect Pituitary ACTH and TSH Cells in Gerbils. Bioelectromagnetics. 2019 Dec 11. doi: 10.1002/bem.22237. Abstract The neuroendocrine system can be modulated by a magnetic field and cerebral ischemia as external and internal stressors, respectively. This study deals with the separate or combined effects of an extremely low frequency (ELF) magnetic field (50 Hz, average magnetic field of 0.5 mT) for 7 days and global cerebral ischemia for 10 min on the morpho-functional features of pituitary adrenocorticotrophic (ACTH) and thyrotrophic (TSH) cells in 3- month-old gerbils. To determine the immediate and delayed effects of the applied stressors, measurements were made on the 7th and 14th days after the onset of the experiment. The ELF magnetic field and 10-min global cerebral ischemia, separately and particularly in combination, decreased (P < 0.05) the volume density of ACTH cells, while only in combination were intracellular ACTH content and plasma ACTH concentration increased (P < 0.05) on day 7. The ELF magnetic field elevated serum TSH concentration on day 7 and intracellular TSHβ content on day 14 (P < 0.05). Also, 10-min global cerebral ischemia alone increased serum TSH concentration (P < 0.05), while in combination with the ELF magnetic field it elevated (P < 0.05) intracellular TSHβ content on day 14. In conclusion, an ELF magnetic field and/or 10-min global cerebral ischemia can induce immediate and delayed stimulation of ACTH and TSH synthesis and secretion. ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

Population3-month-old gerbils

Sample sizeNot supplied

ExposureELF · 0.05 MHz · 7 days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In 3-month-old gerbils, exposure to a 50 Hz (0.5 mT average) ELF magnetic field for 7 days and/or 10-min global cerebral ischemia altered morpho-functional measures of pituitary ACTH and TSH cells. ACTH cell volume density decreased with ELF field and ischemia separately and particularly in combination; intracellular ACTH content and plasma ACTH increased only in the combined condition on day 7. ELF exposure increased serum TSH on day 7 and intracellular TSHβ on day 14; ischemia alone increased serum TSH, and the combined exposure increased intracellular TSHβ on day 14.

Outcomes measured

Pituitary ACTH cell volume density
Intracellular ACTH content
Plasma ACTH concentration
Serum TSH concentration
Intracellular TSHβ content

Limitations

Sample size not reported in provided abstract
Animal study (gerbils), limiting direct generalizability to humans
Co-exposure/stressor (global cerebral ischemia) complicates attribution to ELF magnetic field alone
Outcomes are endocrine/cellular measures; no clinical endpoints reported

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "7 days"
  },
  "population": "3-month-old gerbils",
  "sample_size": null,
  "outcomes": [
    "Pituitary ACTH cell volume density",
    "Intracellular ACTH content",
    "Plasma ACTH concentration",
    "Serum TSH concentration",
    "Intracellular TSHβ content"
  ],
  "main_findings": "In 3-month-old gerbils, exposure to a 50 Hz (0.5 mT average) ELF magnetic field for 7 days and/or 10-min global cerebral ischemia altered morpho-functional measures of pituitary ACTH and TSH cells. ACTH cell volume density decreased with ELF field and ischemia separately and particularly in combination; intracellular ACTH content and plasma ACTH increased only in the combined condition on day 7. ELF exposure increased serum TSH on day 7 and intracellular TSHβ on day 14; ischemia alone increased serum TSH, and the combined exposure increased intracellular TSHβ on day 14.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in provided abstract",
    "Animal study (gerbils), limiting direct generalizability to humans",
    "Co-exposure/stressor (global cerebral ischemia) complicates attribution to ELF magnetic field alone",
    "Outcomes are endocrine/cellular measures; no clinical endpoints reported"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency",
    "ELF magnetic field",
    "50 Hz",
    "0.5 mT",
    "global cerebral ischemia",
    "gerbil",
    "pituitary",
    "ACTH",
    "TSH",
    "TSHβ",
    "neuroendocrine",
    "stressors"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.22237
PubMed: Not supplied

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