RF Safe

Radiofrequency Interference in the Clinical Laboratory

2019 · Harm · Very low evidence

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HarmVery low evidencePaper 1589

An increase in power output from an antenna located ~4 feet from a hematology analyzer was temporally associated with aberrant side scatter and abnormal/erroneous WBC counts. Powering down the antenna returned the instrument to normal working conditions, and …

Study snapshot

Publicationmanual · 2019
Study typecase_report
Reported directionHarm
Evidence ratingVery low

Abstract

Radiofrequency Interference in the Clinical Laboratory Badizadegan ND, Greenberg S, Lawrence H, Badizadegan K. Radiofrequency Interference in the Clinical Laboratory. Am J Clin Pathol. 2019 Apr 2;151(5):522-528. doi: 10.1093/ajcp/aqy174. Abstract OBJECTIVES: Radiofrequency interference (RFI) is a known medical device safety issue, but there are no documented cases of interference resulting in erroneous laboratory results. METHODS: We investigated unexpected failure of a hematology analyzer resulting in erroneous WBC counts. Hardware failure was initially suspected, but temporal association with increased power output from a nearby antenna prompted investigation for RFI. RESULTS: Power output from an antenna located approximately 4 feet from the analyzer was increased to ensure sufficient signal for emergency communications in the building. Interference from the antenna resulted in aberrant side scatter and abnormal WBC counts. Powering down the antenna returned the instrument to normal working conditions. CONCLUSIONS: We have shown RFI as the root cause of erroneous WBC counts in a hematology analyzer. We propose that RFI should be on the list of potential interfering mechanisms when clinical laboratory instruments generate inconsistent or unreliable results. Open access paper: ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typecase_report
Effect directionharm
PopulationNot supplied
Sample sizeNot supplied
ExposureRF
Evidence strengthVery lowConfidence: 74% · Peer reviewed: yes

Main findings

An increase in power output from an antenna located ~4 feet from a hematology analyzer was temporally associated with aberrant side scatter and abnormal/erroneous WBC counts. Powering down the antenna returned the instrument to normal working conditions, and the authors conclude radiofrequency interference was the root cause.

Outcomes measured

  • hematology analyzer performance
  • WBC (white blood cell) count accuracy
  • side scatter signal abnormalities

Limitations

  • Single instrument/event; generalizability unclear
  • No RF frequency or quantitative exposure measurements reported in abstract
  • Potential alternative causes not fully described in abstract
View raw extracted JSON
{
  "study_type": "case_report",
  "exposure": {
    "band": "RF",
    "source": "nearby antenna (emergency communications)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "hematology analyzer performance",
    "WBC (white blood cell) count accuracy",
    "side scatter signal abnormalities"
  ],
  "main_findings": "An increase in power output from an antenna located ~4 feet from a hematology analyzer was temporally associated with aberrant side scatter and abnormal/erroneous WBC counts. Powering down the antenna returned the instrument to normal working conditions, and the authors conclude radiofrequency interference was the root cause.",
  "effect_direction": "harm",
  "limitations": [
    "Single instrument/event; generalizability unclear",
    "No RF frequency or quantitative exposure measurements reported in abstract",
    "Potential alternative causes not fully described in abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "radiofrequency interference",
    "RFI",
    "clinical laboratory",
    "hematology analyzer",
    "white blood cell count",
    "medical device safety",
    "antenna",
    "emergency communications"
  ],
  "suggested_hubs": [
    {
      "slug": "medical-device-interference",
      "weight": 0.9,
      "reason": "Reports radiofrequency interference causing erroneous results in a hematology analyzer due to a nearby antenna."
    },
    {
      "slug": "occupational-exposure",
      "weight": 0.25,
      "reason": "Exposure source is an antenna in a building setting affecting laboratory equipment; relevance is indirect (device interference rather than health outcome)."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1093/ajcp/aqy174
PubMed: Not supplied

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