RF Safe

Effects of acute exposure to ultra-wideband pulsed electromagnetic fields on the liver and kidneys of mice

2020 · Harm · Low evidence

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HarmLow evidencePaper 1578

Acute exposure of mice to ultra-wideband (UWB) pulses altered several blood biochemical parameters and significantly increased ALT and AST. Exposure was associated with increased oxidative stress and could induce lipid droplet accumulation in hepatocytes; hep…

Study snapshot

Publicationmanual · 2020
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

Effects of acute exposure to ultra-wideband pulsed electromagnetic fields on the liver and kidneys of mice Guo K, Zhang Y, Fang X, Fan P, Shang S, Fan F, Wu H, Man M, Xie Y, Lu X. Effects of acute exposure to ultra- wideband pulsed electromagnetic fields on the liver and kidneys of mice. Electromagn Biol Med. 2020 Mar 12:1- 14. doi: 10.1080/15368378.2020.1737806. Abstract The biosafety of ultra-wideband (UWB) pulses, which are characterized by simultaneously high power and a high bandwidth ratio, has gained increasing attention. Although there is substantial prior literature on the biological effects of UWB pulses on both cells and animals, an explicit, unequivocal and definite pattern of the corresponding biological responses remains elusive, and the systemic secondary consequences are also still not fully understood. In this study, we found that exposing mice to UWB pulses resulted in the alteration of several biochemical blood parameters, which further prompted us to investigate changes in the liver and kidneys of mice exposed to UWB pulses with different field intensities and different durations. The data demonstrated that exposure to UWB pulses significantly increased the levels of ALT and AST, increased oxidative stress, and could even induce the accumulation of lipid droplets in hepatocytes. The total number of pulses under the tested acute exposure regiment contributed most to the observed hepatic and rental dysfunction. Notably, the physiological and molecular changes recovered approximately 72 hours after exposure. These results imply the potential risk of acute exposure to UWB pulses, and highlight the meaningful targets for further long-term study of chronic exposure. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
Populationmice
Sample sizeNot supplied
ExposureRF · acute; different durations (not specified)
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Acute exposure of mice to ultra-wideband (UWB) pulses altered several blood biochemical parameters and significantly increased ALT and AST. Exposure was associated with increased oxidative stress and could induce lipid droplet accumulation in hepatocytes; hepatic and renal dysfunction were most influenced by the total number of pulses under the tested acute exposure regimen. Reported physiological and molecular changes recovered approximately 72 hours after exposure.

Outcomes measured

  • blood biochemical parameters
  • ALT
  • AST
  • oxidative stress
  • lipid droplet accumulation in hepatocytes
  • liver dysfunction
  • kidney dysfunction
  • recovery time (~72 hours)

Limitations

  • Sample size not reported in abstract
  • Exposure metrics (e.g., frequency content, SAR) not reported in abstract
  • Specific field intensities and exposure durations not detailed in abstract
  • Acute exposure only; long-term/chronic effects not assessed
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "ultra-wideband pulsed electromagnetic fields",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "acute; different durations (not specified)"
  },
  "population": "mice",
  "sample_size": null,
  "outcomes": [
    "blood biochemical parameters",
    "ALT",
    "AST",
    "oxidative stress",
    "lipid droplet accumulation in hepatocytes",
    "liver dysfunction",
    "kidney dysfunction",
    "recovery time (~72 hours)"
  ],
  "main_findings": "Acute exposure of mice to ultra-wideband (UWB) pulses altered several blood biochemical parameters and significantly increased ALT and AST. Exposure was associated with increased oxidative stress and could induce lipid droplet accumulation in hepatocytes; hepatic and renal dysfunction were most influenced by the total number of pulses under the tested acute exposure regimen. Reported physiological and molecular changes recovered approximately 72 hours after exposure.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure metrics (e.g., frequency content, SAR) not reported in abstract",
    "Specific field intensities and exposure durations not detailed in abstract",
    "Acute exposure only; long-term/chronic effects not assessed"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ultra-wideband",
    "UWB pulses",
    "pulsed electromagnetic fields",
    "mice",
    "liver",
    "kidney",
    "ALT",
    "AST",
    "oxidative stress",
    "lipid droplets",
    "acute exposure"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/15368378.2020.1737806
PubMed: Not supplied

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