The role of curcumin during pregnancy on the exposed fetuses' tissues of Wistar rats to

Electromagnetic biology and medicine · 2024 · Mixed · Low evidence

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MixedLow evidencePaper 256

Study snapshot

PublicationElectromagnetic biology and medicine · 2024

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

The role of curcumin during pregnancy on the exposed fetuses' tissues of Wistar rats to electromagnetic field Kalantar MH, Bayat PD, Ghaffari Khaligh S, Soleimani H. The role of curcumin during pregnancy on the exposed fetuses' tissues of Wistar rats to electromagnetic field. Electromagn Biol Med. 2024 Feb 17:1- 10. doi: 10.1080/15368378.2024.2315214. Abstract To investigate curcumin (CUR) as the protector against the harmful effects of low-frequency electromagnetic field(LF- EMF, 50 Hz) during pregnancy period, 5 males and 15 females of Wistar rat mated and vaginal plaques were observed. Then, the pregnant rats were divided into six groups. During pregnancy(21 days), the EMF group was exposed to EMF for 30 min/day, the CUR group received a single dose of 50 mg/kg/daily CUR intraperitoneal, the EMF+CUR group was injected CUR and exposed to EMF daily. The DMSO(dimethyl sulfoxide) group was injected solvent of CUR (DMSO) intraperitoneal with the same volume of CUR solvent, the sham group was placed through the solenoid in the same conditions as the first group without exposure and the control group was kept in their cage in normal condition. After four weeks, babies born were divided according to the mother groups and sacrificed. Then, the three tissues injuries were investigated. EMF exposure led to an increase in outstanding necrotic areas in hippocampal tissue, an increase in the amount of hyperemia(p = 0.017) and necrotic(p = 0.005) in kidneys, and degeneration in liver tissue(p = 0.007) in the EMF group compared with EMF+CUR groups. A single dose of CUR daily during pregnancy can protect these tissues from injuries caused by LF-EMF exposure in rat fetuses. Plain language summary Electromagnetic fields (EMFs) are able to penetrate and be absorbed by the body. The researchers showed that these radiations might be harmful and lead to cancers, cardiovascular diseases, mental disorders, and fetal abnormalities. Curcumin as an active component in turmeric has anti-inflammatory, antioxidant and anti-hyperlipidemia properties. It can protect the body against diseases such as arthritis, anxiety, and metabolic syndrome. This study examined the effects of curcumin as the protector against the harmful effects of EMF (50Hz) during pregnancy period. So the pregnant rats were divided into six groups. During pregnancy, a group was exposed to EMF for 30 min/day, the second group was injected a dose of curcumin 50mg/kg/daily, the third group was injected curcumin and exposed to EMF daily. The fourth group was injected a curcumin solvent dose, the sham group was placed through the field generator in the same conditions as the first group without exposure and the control group was kept in their cage in normal condition. After four weeks, babies born were divided according to the mother groups and sacrificed. Then, the liver, kidney, and hippocampal tissues were investigated. EMF exposure led to an outstanding increase in necrotic areas in hippocampal tissue, a notable increase in the amount of hyperemia and necrosis in kidneys, and degeneration in liver tissue(p=0.007) in the EMF group compared with the third group that was exposed to EMF and received curcumin. A single dose of curcumin daily during pregnancy can protect these tissues from injuries caused by EMF(50Hz) exposure in rat fetuses. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationPregnant Wistar rats and their offspring (fetuses/pups)

Sample size20

ExposureELF · 30 min/day during pregnancy (21 days)

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In offspring from dams exposed to 50 Hz EMF during pregnancy, the EMF group showed increased necrotic areas in hippocampal tissue, increased kidney hyperemia (p=0.017) and necrosis (p=0.005), and liver degeneration (p=0.007) compared with the EMF+curcumin group. Daily curcumin (50 mg/kg, intraperitoneal) during pregnancy was reported to protect against these tissue injuries associated with LF-EMF exposure.

Outcomes measured

Histological injury/necrosis in hippocampal tissue
Kidney hyperemia
Kidney necrosis
Liver tissue degeneration
Protective effect of curcumin against EMF-associated tissue injury

Limitations

Exposure intensity/field strength not reported in the abstract
Sample size per group not reported in the abstract
Timing of tissue assessment described as 'after four weeks' but details (e.g., exact postnatal age) are unclear in the abstract
Outcomes limited to histological assessments of selected tissues (hippocampus, kidney, liver)

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "solenoid (experimental EMF exposure)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "30 min/day during pregnancy (21 days)"
  },
  "population": "Pregnant Wistar rats and their offspring (fetuses/pups)",
  "sample_size": 20,
  "outcomes": [
    "Histological injury/necrosis in hippocampal tissue",
    "Kidney hyperemia",
    "Kidney necrosis",
    "Liver tissue degeneration",
    "Protective effect of curcumin against EMF-associated tissue injury"
  ],
  "main_findings": "In offspring from dams exposed to 50 Hz EMF during pregnancy, the EMF group showed increased necrotic areas in hippocampal tissue, increased kidney hyperemia (p=0.017) and necrosis (p=0.005), and liver degeneration (p=0.007) compared with the EMF+curcumin group. Daily curcumin (50 mg/kg, intraperitoneal) during pregnancy was reported to protect against these tissue injuries associated with LF-EMF exposure.",
  "effect_direction": "mixed",
  "limitations": [
    "Exposure intensity/field strength not reported in the abstract",
    "Sample size per group not reported in the abstract",
    "Timing of tissue assessment described as 'after four weeks' but details (e.g., exact postnatal age) are unclear in the abstract",
    "Outcomes limited to histological assessments of selected tissues (hippocampus, kidney, liver)"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "curcumin",
    "pregnancy",
    "Wistar rat",
    "low-frequency electromagnetic field",
    "50 Hz",
    "hippocampus",
    "kidney",
    "liver",
    "necrosis",
    "hyperemia",
    "degeneration"
  ],
  "suggested_hubs": [
    {
      "slug": "elf-emf",
      "weight": 0.9,
      "reason": "Animal study of low-frequency (50 Hz) EMF exposure during pregnancy."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/15368378.2024.2315214
PubMed: 38366892

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