Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats

2022 · Mixed · Low evidence

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MixedLow evidencePaper 1269

Study snapshot

Publicationmanual · 2022

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats Azizi E, Ayoobi F, Shamsizadeh A, Moghadam-Ahmadi A, Shafiei S A, Khoshdel A et al . Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats. BCN 2022; 13 (4) :519- 530. Abstract Introduction: Lack of high-quality sleep causes severe side effects like anxiety and changes in plasma concentration of oxalate. The current study investigated the impact of local extremely low-frequency magnetic fields (ELF-MFs) on inducing sleep (sleepiness) and anxiety in male rats. Methods: In this experimental study, 40 male rats were divided into four groups (n=10 for each group). The ELF- MF exposure (0, 10, and 18 Hz) was applied with an intensity of 200µT for three days (10 min/d). The sham- treated animal did not receive ELF-MF. Serum levels of oxalic acid (OA) and sleepiness were measured before and after the last exposure to ELF-MF or sham. Anxiety, sleepiness, and OA were measured using the elevated plus maze, open-field test (OFT), and ELISA test. Results: A comparison of oxalate levels before and after exposure to ELF-MF revealed that ELF-MF (10 Hz) decreased the serum level of oxalate (P<0.05). Comparing open/closed arm entry (in an elevated plus maze) between before and after exposure to ELF-MF revealed significant differences. Also, frequency, velocity, and distance moved were decreased in the open-field test. Conclusion: Results of the present study demonstrated that ELF-MF with short-time exposure may modulate the metabolism of OA and may modulate anxiety-like behavior or kind of induction of sleepiness in male rats. Open access paper: bcn.iums.ac.ir

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationMale rats

Sample size40

ExposureELF · 3 days (10 min/day)

Evidence strengthLowConfidence: 74% · Peer reviewed: unknown

Main findings

In 40 male rats, short-time local ELF magnetic field exposure (200 µT; 0, 10, or 18 Hz; 10 min/day for 3 days) was associated with a decrease in serum oxalate at 10 Hz (P<0.05). Behavioral measures showed significant before/after differences in elevated plus maze open/closed arm entry and decreased frequency, velocity, and distance moved in the open-field test; authors interpret these as modulation of anxiety-like behavior and/or induction of sleepiness.

Outcomes measured

Sleepiness
Anxiety-like behavior (elevated plus maze, open-field test)
Serum oxalic acid/oxalate levels

Limitations

Short exposure duration (3 days; 10 min/day)
Animal study (male rats only)
Local exposure; generalizability to other exposure scenarios unclear
Details on blinding/randomization not provided in abstract
Results described as before/after comparisons; between-group effects not fully detailed in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "local magnetic field exposure",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "3 days (10 min/day)"
  },
  "population": "Male rats",
  "sample_size": 40,
  "outcomes": [
    "Sleepiness",
    "Anxiety-like behavior (elevated plus maze, open-field test)",
    "Serum oxalic acid/oxalate levels"
  ],
  "main_findings": "In 40 male rats, short-time local ELF magnetic field exposure (200 µT; 0, 10, or 18 Hz; 10 min/day for 3 days) was associated with a decrease in serum oxalate at 10 Hz (P<0.05). Behavioral measures showed significant before/after differences in elevated plus maze open/closed arm entry and decreased frequency, velocity, and distance moved in the open-field test; authors interpret these as modulation of anxiety-like behavior and/or induction of sleepiness.",
  "effect_direction": "mixed",
  "limitations": [
    "Short exposure duration (3 days; 10 min/day)",
    "Animal study (male rats only)",
    "Local exposure; generalizability to other exposure scenarios unclear",
    "Details on blinding/randomization not provided in abstract",
    "Results described as before/after comparisons; between-group effects not fully detailed in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "unknown",
  "keywords": [
    "extremely low-frequency",
    "ELF-MF",
    "magnetic field",
    "200 µT",
    "10 Hz",
    "18 Hz",
    "sleepiness",
    "anxiety",
    "elevated plus maze",
    "open-field test",
    "oxalic acid",
    "oxalate",
    "rats"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: Not supplied

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