Changes in growth kinetic parameters, morphology and mitotic activity of yeasts Candida guilliermondii exposed to the low-intensity waves of 51.8-GHz frequency

Archives of microbiology · 2021 · Harm · Low evidence

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HarmLow evidencePaper 1153

Exposure to low-intensity 51.8 GHz electromagnetic waves was associated with morphological changes (appearance of filamentous and giant cells), an increased lag phase duration by 2 hours, delayed subsequent growth phases, and decreased specific growth rate, m…

Study snapshot

PublicationArchives of microbiology · 2021

Study typein_vitro

Reported directionHarm

Evidence ratingLow

Abstract

Changes in growth kinetic parameters, morphology and mitotic activity of yeasts Candida guilliermondii exposed to the low-intensity waves of 51.8-GHz frequency Seda Marutyan, Syuzan Marutyan, Liparit Navasardyan, Karlen Hovnanyan, Armen Trchounian. Changes in growth kinetic parameters, morphology and mitotic activity of yeasts Candida guilliermondii exposed to the low- intensity waves of 51.8-GHz frequency. Arch Microbiol. 2021 May 3. doi: 10.1007/s00203-021-02336-0. Abstract Under the influence of electromagnetic waves of millimeter range with the frequency of 51.8 GHz, changes in the morphology, growth parameters and mitotic activity of yeasts C. guilliermondii NP-4 are revealed. Filamentous and giant cells appeared in a population of exposed yeasts. The sigmoid shape of the growth curve remained but the lag phase duration was increased by 2 h in comparison with non-exposed yeasts; accordingly, the log and stationary phases followed 2 h later. The specific growth rate in the log growth phase and colony- forming ability of exposed yeasts was decreased. It is suggested that yeasts have some response mechanisms to 51.8-GHz frequency electromagnetic waves. The results can be used to understand the response mechanisms of microorganisms to non-ionizing radiation, as well as to develop approaches to protect living organisms from it. The effect of electromagnetic waves of 51.8-GHz frequency to suppress yeasts can be applied in biotechnology and medicine. pubmed.ncbi.nlm.nih.gov Excerpt EHF EMR (ν = 51.8 GHz) was used in the amplitude modulation mode with a frequency of 1 Hz (signal frequency stability was 0.05%). A low-intensity EMR (flow power of 0.06 mW cm–2) was applied (Hovnanyan et al. 2017; Soghomonyan and Trchounian 2018; Torgomyan et al. 2012) .... Summarizing a comparative study of the effects of low-intensity electromagnetic waves with a frequency of 51.8 GHz on the yeast C. guilliermondii NP-4, it can be concluded that electromagnetic waves of the frequency of 51.8 GHz lead to changes in the morphology of yeast cells, to decreases in their growth, mitotic activity and colony-forming ability. These results increase interest in further studying the effects of EMR of other EHF on yeasts and other cells. Based on the fact that yeasts are a convenient model for studying higher eukaryotes, it is appropriate to assume that electromagnetic waves with a frequency of 51.8 GHz will have the same overwhelming effect on the growth of higher eukaryotes. From this point of view, based on our results, it can be assumed that abuse of cellular communications is dangerous not only for microorganisms, but also for higher eukaryotes, in particular for human health. The results can be used to elucidate the response mechanisms of living organisms to radiation stress, as well as to develop approaches for protecting living organisms from non-ionizing radiation. In addition, they can be useful in biotechnology and medicine to suppress yeast, when pathogenic species cause various diseases.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionharm

PopulationYeast Candida guilliermondii (strain NP-4)

Sample sizeNot supplied

ExposuremmWave · 51800 MHz

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Morphology (filamentous and giant cells)
Growth curve parameters (lag phase duration, log/stationary phase timing)
Specific growth rate (log phase)
Mitotic activity
Colony-forming ability

Limitations

No exposure duration reported in the provided abstract/excerpt
No sample size or number of replicates reported in the provided abstract/excerpt
No quantitative effect sizes or statistical details reported in the provided abstract/excerpt
In vitro yeast model; generalization beyond this organism is not established in the provided text

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "mmWave",
    "source": null,
    "frequency_mhz": 51800,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Yeast Candida guilliermondii (strain NP-4)",
  "sample_size": null,
  "outcomes": [
    "Morphology (filamentous and giant cells)",
    "Growth curve parameters (lag phase duration, log/stationary phase timing)",
    "Specific growth rate (log phase)",
    "Mitotic activity",
    "Colony-forming ability"
  ],
  "main_findings": "Exposure to low-intensity 51.8 GHz electromagnetic waves was associated with morphological changes (appearance of filamentous and giant cells), an increased lag phase duration by 2 hours, delayed subsequent growth phases, and decreased specific growth rate, mitotic activity, and colony-forming ability compared with non-exposed yeasts.",
  "effect_direction": "harm",
  "limitations": [
    "No exposure duration reported in the provided abstract/excerpt",
    "No sample size or number of replicates reported in the provided abstract/excerpt",
    "No quantitative effect sizes or statistical details reported in the provided abstract/excerpt",
    "In vitro yeast model; generalization beyond this organism is not established in the provided text"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "Candida guilliermondii",
    "yeast",
    "millimeter waves",
    "EHF",
    "51.8 GHz",
    "low-intensity",
    "amplitude modulation",
    "growth kinetics",
    "morphology",
    "mitotic activity",
    "colony-forming ability"
  ],
  "suggested_hubs": [
    {
      "slug": "5g-policy",
      "weight": 0.32,
      "reason": "Study involves millimeter-wave frequency (51.8 GHz), relevant to mmWave discussions, though not explicitly about 5G systems."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/s00203-021-02336-0
PubMed: 33938972

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