Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation

2021 · No effect · Low evidence

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No effectLow evidencePaper 1047

Study snapshot

Publicationmanual · 2021

Study typeother

Reported directionNo effect

Evidence ratingLow

Abstract

Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation D S Sitnikov, A A Pronkin, I V Ilina, V A Revkova, M A Konoplyannikov, V A Kalsin, V P Baklaushev. Numerical modelling and experimental verification of thermal effects in living cells exposed to high-power pulses of THz radiation. Sci Rep. 2021 Sep 9;11(1):17916. doi: 10.1038/s41598-021-96898-0. Abstract Exposure of cells or biological tissues to high-power pulses of terahertz (THz) radiation leads to changes in a variety of intracellular processes. However, the role of heating effects due to strong absorption of THz radiation by water molecules still stays unclear. In this study, we performed numerical modelling in order to estimate the thermal impact on water of a single THz pulse as well as a series of THz pulses. A finite-element (FE) model that provides numerical solutions for the heat conduction equation is employed to compute the temperature increase. A simple expression for temperature estimation in the center of the spot of THz radiation is presented for given frequency and fluence of the THz pulse. It has been demonstrated that thermal effect is determined by either the average power of radiation or by the fluence of a single THz pulse depending on pulse repetition rate. Human dermal fibroblasts have been exposed to THz pulses (with an energy of [Formula: see text] and repetition rate of 100 Hz) to estimate the thermal effect. Analysis of heat shock proteins expression has demonstrated no statistically significant difference ([Formula: see text]) between control and experimental groups after 3 h of irradiation. Open access paper: nature.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionno_effect

PopulationNot supplied

Sample sizeNot supplied

ExposureTHz · 3 h irradiation; pulses at 100 Hz

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Finite-element modelling was used to estimate temperature increases in water from single and repeated THz pulses, with thermal effect depending on average power or single-pulse fluence depending on repetition rate. In experiments, human dermal fibroblasts exposed to THz pulses (100 Hz) showed no statistically significant difference in heat shock protein expression between control and exposed groups after 3 h of irradiation.

Outcomes measured

Temperature increase/thermal impact in water from THz pulses (numerical modelling)
Heat shock proteins expression in human dermal fibroblasts after THz pulse exposure

Limitations

Specific THz frequency not stated in the provided abstract text
Pulse energy value not readable in the provided abstract (shown as a formula placeholder)
Sample size and detailed experimental conditions not provided in the abstract
Outcomes limited to heat shock protein expression for the experimental verification described

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": "THz",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "3 h irradiation; pulses at 100 Hz"
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Temperature increase/thermal impact in water from THz pulses (numerical modelling)",
    "Heat shock proteins expression in human dermal fibroblasts after THz pulse exposure"
  ],
  "main_findings": "Finite-element modelling was used to estimate temperature increases in water from single and repeated THz pulses, with thermal effect depending on average power or single-pulse fluence depending on repetition rate. In experiments, human dermal fibroblasts exposed to THz pulses (100 Hz) showed no statistically significant difference in heat shock protein expression between control and exposed groups after 3 h of irradiation.",
  "effect_direction": "no_effect",
  "limitations": [
    "Specific THz frequency not stated in the provided abstract text",
    "Pulse energy value not readable in the provided abstract (shown as a formula placeholder)",
    "Sample size and detailed experimental conditions not provided in the abstract",
    "Outcomes limited to heat shock protein expression for the experimental verification described"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "terahertz",
    "THz radiation",
    "high-power pulses",
    "thermal effects",
    "finite-element model",
    "heat conduction",
    "water absorption",
    "human dermal fibroblasts",
    "heat shock proteins"
  ],
  "suggested_hubs": [
    {
      "slug": "5g-policy",
      "weight": 0.15,
      "reason": "Study concerns THz radiation, which can be relevant to discussions of higher-frequency wireless technologies, but no explicit 5G context is stated."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1038/s41598-021-96898-0
PubMed: Not supplied

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