Short-Term Extremely Low-Frequency Electromagnetic Field Inhibits Synaptic Plasticity of Schaffer Collateral- CA1 Synapses in Rat Hippocampus via the Ca 2+/Calcineurin Pathway

ACS chemical neuroscience · 2021 · Harm · Low evidence

← Research stream

HarmLow evidencePaper 1043

Using electrophysiological techniques in the rat hippocampal SC-CA1 region, ELF-EMF exposure weakened long-term potentiation and enhanced long-term depression. The reported magnetic field effects disappeared after blockade of voltage-gated calcium channels (c…

Study snapshot

PublicationACS chemical neuroscience · 2021

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Short-Term Extremely Low-Frequency Electromagnetic Field Inhibits Synaptic Plasticity of Schaffer Collateral- CA1 Synapses in Rat Hippocampus via the Ca 2+/Calcineurin Pathway Pei Xia, Yu Zheng, Lei Dong, Chunxiao Tian. Short-Term Extremely Low-Frequency Electromagnetic Field Inhibits Synaptic Plasticity of Schaffer Collateral-CA1 Synapses in Rat Hippocampus via the Ca 2+/Calcineurin Pathway. ACS Chem Neurosci. 2021 Sep 9. doi: 10.1021/acschemneuro.1c00500. Abstract In this study, we investigate the intrinsic mechanism by which an extremely low-frequency electromagnetic field (ELF-EMF) influences neurons in the Schaffer collateral-CA1 (SC-CA1) region of rat hippocampus using electrophysiological techniques. ELF-EMF has an interesting effect on synaptic plasticity: it weakens long-term potentiation and enhances long-term depression. Here, the magnetic field effect disappeared after a blockade of voltage-gated calcium channels and calcineurin, which are key components in the Ca2+/calcineurin pathway, with two blockers, cadmium chloride and cyclosporin A. This fully establishes that the effect of ELF-EMF on synaptic plasticity is mediated by the Ca2+/calcineurin pathway and represents a novel technique for studying the specific mechanisms of action of ELF-EMF on learning and memory. pubmed.ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationRat hippocampus (Schaffer collateral-CA1 region)

Sample sizeNot supplied

ExposureELF · short-term

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Synaptic plasticity
Long-term potentiation (LTP)
Long-term depression (LTD)
Involvement of Ca2+/calcineurin pathway (via blockade of voltage-gated calcium channels and calcineurin)

Limitations

Frequency and field strength not reported in the abstract
Exposure source and detailed exposure conditions not reported in the abstract
Sample size not reported in the abstract
Short-term exposure only; longer-term effects not addressed in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "short-term"
  },
  "population": "Rat hippocampus (Schaffer collateral-CA1 region)",
  "sample_size": null,
  "outcomes": [
    "Synaptic plasticity",
    "Long-term potentiation (LTP)",
    "Long-term depression (LTD)",
    "Involvement of Ca2+/calcineurin pathway (via blockade of voltage-gated calcium channels and calcineurin)"
  ],
  "main_findings": "Using electrophysiological techniques in the rat hippocampal SC-CA1 region, ELF-EMF exposure weakened long-term potentiation and enhanced long-term depression. The reported magnetic field effects disappeared after blockade of voltage-gated calcium channels (cadmium chloride) and calcineurin (cyclosporin A), suggesting mediation via the Ca2+/calcineurin pathway.",
  "effect_direction": "harm",
  "limitations": [
    "Frequency and field strength not reported in the abstract",
    "Exposure source and detailed exposure conditions not reported in the abstract",
    "Sample size not reported in the abstract",
    "Short-term exposure only; longer-term effects not addressed in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low-frequency electromagnetic field",
    "ELF-EMF",
    "hippocampus",
    "Schaffer collateral-CA1",
    "synaptic plasticity",
    "long-term potentiation",
    "long-term depression",
    "Ca2+",
    "calcineurin",
    "cadmium chloride",
    "cyclosporin A",
    "electrophysiology"
  ],
  "suggested_hubs": [
    {
      "slug": "elf-emf",
      "weight": 0.9,
      "reason": "Study explicitly investigates extremely low-frequency electromagnetic field (ELF-EMF) effects."
    },
    {
      "slug": "mechanisms-calcium-signaling",
      "weight": 0.75,
      "reason": "Findings implicate voltage-gated calcium channels and the Ca2+/calcineurin pathway."
    }
  ]
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1021/acschemneuro.1c00500
PubMed: 34498467

Read the original paper →

Related papers

← Back to the Research Library